12-Deoxyroyleanone (1), an abietane diterpenoid with appreciable antileishmanial activity, has been efficiently synthesized from abietic acid (10; 11 steps for a 25% overall yield).
Terpenes U 0200First Enantiospecific Synthesis of Antileishmanial 12-Deoxyroyleanone from Abietic Acid. -The title compound (I) is prepared from abietic acid in 11 steps and 25% overall yield. -(ALVAREZ-MANZANEDA ROLDAN*, E. J.; CHAHBOUN, R.; BENTALEB, F.; CABRERA TORRES, E.; ALVAREZ, E.; HAIDOUR, A.; RAMOS LOPEZ, J. M.; ALVAREZ-MANZANEDA ROLDAN, R.; EL HOUSSAME, S.; Synlett 2004, 15, 2701-2704; Dep. Quim. Org.,
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