Racemic methadone is increasingly used to manage cancer pain. The authors studied 13 terminally ill patients with cancer pain, who underwent switching (rotation) from morphine to methadone. The relationship between initial morphine dose and final methadone dose, the pharmacokinetics of R- and S- methadone, and the degree of pain control and side effects were investigated. Preswitching serum morphine concentrations and second daily plasma concentrations of methadone were measured. The brief pain inventory (BPI) was used to assess pain every second day. "Worst pain" as measured by the BPI improved by >/=20% in 6 of the 13 patients. The mean morphine to methadone conversion ratio was 5.2 with wide interpatient variability (range 1.3 to 11). Average steady-state concentrations were 197 (98 to 379) mug/L and 272 (55 to 378) mug/L for R- and S-methadone, respectively. Mean population pharmacokinetic parameters for a 1-compartment model were 455 L and 338 L for apparent volume of distribution and 53.3 hours and 31.5 hours for half-life for R- and S- methadone, respectively. Bayesian estimates of apparent oral clearance for individual patients were 0.082 (0.052 to 0.112) L/kg/h and 0.117 (0.061 to 0.173) L/kg/h for R- and S- methadone, respectively (mean and 95% confidence interval). The low and variable clearance values generally resulted in slow achievement of steady-state concentrations over several days; inappropriately high plasma methadone levels occurred in 1 patient. Whereas optimal pain control was achieved in 46% of patients, there was no relationship with plasma concentrations of methadone. Best practice for methadone use in this patient group should include monitoring of both pain and methadone concentration.

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There is no denying the fact that the modern age appreciates beauty of the home and grounds more than ever before. This is why the vogue of beautiful grounds is captivating the country, and ivhy everyone will soon be exemplifying the idea that "It's Not a Home Until It's Planted." We employ this method of soliciting your order, for you can check over your requirements at your leisure, and only buy what you need AT A BIG SAVING-If we were to employ agents to call on you and other per¬ sons, it would involve considerable expense, 30 to 50 per cent more than we now ask, consequently, calling by mail results is a big saving, tvhich ive are passing on to you in these loiv prices on hardy, healthy, vigorous nursery stock. It is easy to order by mail. Just fill in the enclosed order blank, being particular to specify just what is wanted. Your name, post office and shipping point should be written plainly to avoid mistakes. These prices are F. 0. B. McMinnville. No charge for packing. Ornamental Shrubs This ornamental shrub group includes all those deciduous, blooming and berry-bearing plants that are ordinarily called shi'ubs. They naturally cover a wide range as to size, from dwarf to those that are tall enough for screens. In color of blossom, character of growth, etc., you will find something suited for every location. By only a very small investment you will greatly increase, not only the beauty of the home grounds, but add money value as well. PRIVET. We are large growers of the Ligustrum Privet, in varieties. For live fences at village, town and country homes, it is the very best of all materials. On public grounds of all kinds, in parks and cemeteries, along roads and paths, on fac¬ tory grounds, and in new subdivided areas, nothing else can be used to take its place. Amur River North Privet. Very hardy and widely used in the North. Per 10 Per 100 12 to 18 inch branched.? .50 $3.00 18 to 24 inch branched.60 3.50 2 to 3 feet branched.75 4.50 3 to 4 feet branched. 1.00 6.00 Amur River South Privet. Where winter season is not too severe, will retain its foliage the entire year. Rich green foliage, compact in growth. 12 to 18 inch branched.50 3.00 18 to 24 inch branched.60 3.50 2 to 3 feet branched.75 4.50 3 to 4 feet branched.. .. 1.00 6.00 California Privet. Thick, glossy green foliage, nearly ever¬ green. 12 to 18 inch branched. 30 2.00 18 to 24 inch branched.50 3.00 2 to 3 feet branched.75 4.00 3 to 4 feet branched. 1.00 6.00 Ibota Privet. A Japanese variety of beautiful character. Dark oval foliage and white flowers. Very hardy. 12 to 18 inch branched.30 2.00 18 to 24 inch branched.50 3.00 2 to 3 feet branched.75 4.00 3 to 4 feet branched. .. 1.00 6.00 ALMOND, Amygdalus. We offer these in pink only. One of our most attractive ornamental shrubs. Early in the season every twig and branch is brilliant with the beautiful flowers. Each Per 10 18 to 24 inch.... . $0.35 $3.00 ALTHEAS. Beautiful bell-shaped flowers from August until frost. Grows 6 to 8 feet. Anemonaeflorus. Large, double red. Amplissima. Double, rosy-re...

The First National Bank McMinnvii.le.Texn June 26 tli. 1929. To Whom It Kay Concern:-Vie have had a long business con¬ nection and association with Mr.P.C.Boyd,who is to be the manager and principal owner of Boyd Nursery Company,which has recently taken over the retail nureery business of the Forest Nursery Company of tills city. The latter company will in the future be exclusively in the wholesale nureery business. Ur.F.C.Boyd has retired from the presidency of the Forest Nursery Company,having disposed of his interest therein. Bpyd Nursery Company will be managed and operated on the same high plane as the other companies in which Ur.F.C.Boyd has been interested and its product# will be sold under the same guarantee of satisfaction to the customer and we have reason to know the company will be wil¬ ling and able to fulfill its contracts. Mr.Boyd stand high with his craft and with this community. He is a high-toned,honorable gen¬ tleman in whom we have great confidence. He is thorough¬ ly familiar with the nureery business having made it his 'life's study and business and has been successful in it. We heartily recommend Boyd Nursery Company to prospective customers whom we believe will at all times receive,at their hands,a square deal. Peonies Like These are Easy to Grow. This Variety is Festiva Maxima, See page 52. Helpful Hints Trees out of ground, are like fish out of water. Exercise every care in handling stock to insure it growing. With every order of nursery stock, we send a Planting Booklet. It tells how to plant, prune and care for trees, shrubs and evergreens. No agents; we prefer to sell direct to our patrons. By this method you have reasonable assurance that our firm is responsible. If the stock is not what it should be, you know where you got it, let us know. Constructive criticism is always helpful. Place your order early. Our shipping season is crowded into a few weeks each Fall and Spring. We can reserve for you plenty of good material, if you advise us of your requirements in time.