Tackykinins are involved in the inflammatory process of a large number of diseases. The role of the tachykinins in ischemic brain injury was evaluated by the serum levels of Substance P (SP), one of the most known tachykinins and detected by a competitive enzyme immunoassay. The study was performed in 15 human females and 3 human males with typical manifestation of complete stroke (12 cases) or transient ischemic attack (6 cases). The mean SP level in the serum of patients with transient ischemic attack (0.53+/-0.25 ng/ml) and of patients with complete stroke (0.31+/-0.14 ng/ml), showed significantly higher values than in controls (0.10+/-0.02 ng/ml). Moreover, in transient ischemic attack, the SP values were significantly higher than in cerebral complete stroke. But SP levels, based on the timings of classification of patients (i.e. before 12 hours: 0.34+/-0.15 ng/ml vs. 12 to 24 hours: 0.26+/-0.11 ng/ml) with brain injury, did not show any significant difference. Both values anyway were significantly higher than in controls. Our original results demonstrate the SP increase during cerebral ischemia. Further studies are necessary to verify if SP has an effective physiopathological role in the neurological ischemic damage, or if it is only a concomitant phenomenon. Our data, if confirmed, will be particularly important, not only to improve the knowledge of cerebral ischemic injury, but also for diagnosis and therapeutic approaches.

As the only gravity theory with quadratic curvature terms and second-order field equations, Einstein-dilaton-Gauss-Bonnet gravity is a natural testbed to probe the high-curvature regime beyond General Relativity in a fully nonperturbative way. Due to nonperturbative effects of the dilatonic coupling, black holes in this theory have a minimum mass which separates a stable branch from an unstable one. The minimum mass solution is a double point in the phase diagram of the theory, wherein the critical black hole and a wormhole solution coexist. We perform extensive nonlinear simulations of the spherical collapse onto black holes with scalar hair in this theory, especially focusing on the region near the minimum mass. We study the nonlinear transition from the unstable to the stable branch and assess the nonlinear stability of the latter. Furthermore, motivated by modeling the mass loss due to Hawking radiation near the minimum mass at the classical level, we study the collapse of a phantom field onto the black hole. When the black-hole mass decreases past the critical value, the apparent horizon shrinks significantly, eventually unveiling a high-curvature elliptic region. We argue that evaporation in this theory is bound to either violate the weak cosmic censorship or to produce horizonless remnants. Addressing the end-state might require a different evolution scheme.

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We perform extensive nonlinear numerical simulations of the spherical collapse of (charged) wave packets onto a charged black hole within Einstein-Maxwell theory and in Einstein-Maxwell-scalar theory featuring nonminimal couplings and a spontaneous scalarization mechanism. We confirm that black holes in full-fledged Einstein-Maxwell theory cannot be overcharged past extremality and no naked singularities form, in agreement with the cosmic censorship conjecture. We show that naked singularities do not form even in Einstein-Maxwell-scalar theory, although it is possible to form scalarized black holes with charge above the Reissner-Nordström bound. We argue that charge and mass extraction due to superradiance at the fully nonlinear level is crucial to bound the charge-to-mass ratio of the final black hole below extremality. We also discuss some "descalarization" mechanisms for scalarized black holes induced either by superradiance or by absorption of an opposite-charged wave packet; in all cases the final state after descalarization is a subextremal Reissner-Nordström black hole.