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MEDICAL MEMORANDA MEDIALJISOHRNAL of drug). The initial smaller dose-was to minimize any tendency there might be to a sharp reactive rise of temperature on beginning treatment-a tendency reported in the series of Spink et al.After starting the drug the pyrexia, which had been broadly of an intermittent pattern swinging between limits of 97 and 102' F. (36.1 and 38.9°C.), became in about 24 hours more continuous and reached over i03°F. (39.4°C.); in a further 36 hours it began to fall rapidly and reached normal in about another 24 hours, where it remained. It was still steadily normal 10 days later, when the patient's wish to return home was acceded to (April 22). and on interviewing him on May 12 he reported continued freedom from his former febrile sensations, and a single check on his temperature gave a normal level.The drug was easily administered and caused no apparent toxic reactions.

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