No abstract

With a brother and sister, osteosarcoma developed at the age of 11 and 14 respectively. With both there was no previous retinoblastoma or other bone disease with a proclivity to develop osteosarcoma. We discuss possible explanations for familial aggregation of osteosarcoma, citing external or genetic factors. We suggest that it is the retinoblastoma gene RB and the tumor suppressor gene p53 which play an important part in the development of osteosarcoma.

The Oxystat-photometer (Fa. Andos) is a new instrument for measuring of oxygen content and haemoglobin of blood. Using specific agents oxygen and haemoglobin can be registered in small cuvettes. The principle of measurement is photometry. Additionally O2-saturation can be calculated. In 139 experiments we checked the reliability of the Oxystat-photometer in comparison to the Lex-O2-Con (Lexington Instruments Corporation). High significance could be demonstrated (r = 0.96). There was a range from the control value below 5%. Following investigations using calculation, results could be confirmed.