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A chiral crown ether Is successfully used as a pseudo stationary phase In capillary zone electrophoresis to separate optically active amines. On the basis of the results obtained from the separation of more than 20 amines, two recognition mechanisms are proposed: (I) the four crown ether substituents act as chiral barriers for the guest molecules and (II) lateral electrostatic Interactions occur between host and guest. These results are confirmed by thermodynamic studies on the hostguest complexes. Best resolutions are achieved If the chiral center Is adjacent to the amine functionality. However, even racemates with a chiral center In the ^-position to the amine could be resolved excellently. For the separation of aliphatic amino acids a method has been developed allowing detection by an Indirect detection mode.

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