Tranexamic acid reduces blood losses and transfusion requirements even when a blood conservation program was used and it questions the usefulness of the postoperative reinfusion drains.

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SummaryA randomised double-blind comparison of oral famotidine and ranitidine given 2 hours before induction, on gastric secretion (volume and p H ) was carried out on 93 patients undergoing elective surgery. Gastric contents were aspirated immediately after tracheal intubation. Famotidine significantly reduced the gastric volume, compared with the other groups, including ranitidine. Both famotidine and ranitidine significantly elevated gastric p H towards neutral, compared with the other groups. There was no significant difference between ranitidine and famotidine in respect of the p H . The patients prernedicated with farnotidine and ranitidine were well protected against Mendelson's syndrome, whereas 38% of patients from the other groups remained at risk.

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