The results of SLNB after PC are comparable to the results of SLNB without PC. Further investigation in a prospective setting is warranted to confirm these promising results.

Preoperative breast biopsy might cause disaggregation of tumour cells and tumour cell spread. The purpose of this study was to investigate the impact of preoperative biopsy on the rate of metastases to the sentinel lymph node (SLN) of patients with primary breast cancer. We report the results of 2502 patients with primary breast cancer, who were operated, and a sentinel node biopsy was performed. The association of preoperative biopsy with the risk of SLN metastases was examined by regression analyses and tested for possible confounding well-known factors for axillary node metastases. In all, 1890 patients were available for final analyses; 1048 (55.4%) patients had a preoperative diagnosis performed by fine-needle aspiration or core biopsy; 641 (33.9%) patients had a positive SLN when conventional H&E and IHC staining was performed. Patients with preoperative breast biopsy showed a 1.37 times (95% CI, 1.13 -1.66) increased risk of SLN metastases on univariate analysis, but this result was not persistent when analysis was adjusted for other relevant factors for axillary node metastases, OR 1.09 (95% CI, 0.85 -1.40). In addition, subgroup analyses of the risk for occult micro metastases to the SLN (detected by IHC only) on H&E-negative cases also showed no increased risk associated with preoperative biopsy, OR 1.07 (95% CI, 0.69 -1.65). The conclusion, based on the present data, is that preoperative breast biopsy does not cause artificial tumour cell spread to the SLN, with possible negative impact on the prognosis of breast cancer.

The results of SLNB after PC are comparable to the results of SLNB without PC. Further investigation in a prospective setting is warranted to confirm these promising results.

Breast-conserving therapy is a safe and cosmetically acceptable alternative to mastectomy for subareolar breast cancer.

Background: Sentinel lymph node detection with radiocolloids is confronted with the same problem as the blue dye (BL) method: Even now there is no standardized procedure as regards the application method, the amount of radioactivity and injected volume of the radiocolloid (RC). Therefore, our aim was to find out the most reliable application method and to evaluate a possible tumour-site dependence of detectability. Methods: Until 1 November 2001, 1567 patients with primarily diagnosed breast cancer and SNB were collected in a nationwide multicentric database (MCDBP, Multicentre Database Project) of the Austrian Sentinel Node Biopsy Study Group (ASNSG). 1116 patients (71.2 %) with radiocolloid detection of the sentinel node (SN), either alone or in combination with blue dye, were included in this evaluation. Exclusion criteria were tumour size > 3 cm, multicentric carcinoma, previous chemotherapy or extensive surgical intervention, enlarged axillary lymph nodes, pregnancy, and lactation. The influence of the injection technique (peritumoral [PT], subdermal [SD] application) and tumour location on the lymphatic drainage pathway and the detection rates were evaluated. Results: On lymphoscintigraphy, drainage to axillary lymph nodes could be detected in 86 % (468/544) using PT, and in 80.1 % (273/341) using SD. Lymphatic drainage to parasternal SNs could be primarily observed using PT in 3.7 % (20/544). Intraoperatively, slightly higher detection rates could be observed only in tumours located in the inner-upper quadrants using PT (73/83; 88 %) as compared with SD (98/124; 79 %). Intraoperative detection rates for medially and laterally located tumours were comparable for PT (89.5 % vs. 90.5 %), but demonstrated inferior results for medially (68.4 %) vs. laterally (80.7 %) located tumours for SD. Conclusions: In conclusion, as regards axillary SNs, the detection rates of PT and SD seem to be comparable, whereas parasternal SNs seem to be detected more frequently by PT. A dependence on the primary tumour site could be demonstrated only for the inner quadrants, with detection rates being higher with PT than with SD. As a consequence, PT demonstrates advantages in terms of complete lymphatic mapping, independent of tumour location, and would be the method of choice for sentinel node biopsy.Eur. Surg. 2002; 34:267±271) Identifizierung des Wa Èchterlymphknotens beim Mammakarzinom mittels Lymphoszintigraphie und Gammasonde: Abha Èngigkeit von der Applikationsmethode und der Lokalisation des Prima Èrtumors Zusammenfassung: Grundlagen: Analog zur Blaufarbstoffmethode (BL) existiert auch fu Èr den nuklearmedizinischen Nachweis des Sentinellymphknoten (SN) beim Mammakarzinom bislang kein standardisiertes Vorgehen bezu Èglich Injektionsart, -ort, verabreichter Aktivita Èt und Volumen des Radiokolloids (RC). Die Fragestellung dieser Arbeit war, welche Injektionsmethode die ho Èchste Detektionsrate aufweist und ob eine Abha Èngigkeit vom Sitz des Prima Èrtumors besteht. Methodik: Bis 1. 11. 2001 wurden 1567 Patientinnen mit erstd...