Resumo Foi avaliada a atividade antiparasitária do alopurinol, referente ao Trypanosoma cruzi, através de procedimento que depende da utilização de triatomíneos infectados. De acordo com a metodologia usada, o fármaco não eliminou o protozoário do tubo digestivo dos insetos. Não ocorreu, portanto, obtenção de novo subsídio para melhor entendimento da posição do alopurinol no contexto do tratamento etiológico da infecção pelo T. cruzi, porquanto ela continua em foco, se bem que eivada de divergências e contradições. Palavras-chaves: Trypanosoma cruzi. Alopurinol. Atividade no tubo digestivo de triatomíneos.
AbstractThe antiparasitic activity of allopurinol, against Trypanosoma cruzi, was evaluated by a procedure using infected triatomines. This methodology indicated that the drug was unable to eliminate the protozoa in the digestive tract of the insects. Therefore, further knowledge to improve our understanding of allopurinol in the context of the etiologic treatment of infection by T. cruzi was not acquired. Despite this finding the drug continues to be used, even though its performance appears to be full of divergences and contradictions. Key-words: Trypanosoma cruzi. Allopurinol. Activity in the digestive tract of triatomines.
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