Monkeypox, an emergent zoonotic disease caused by an orthopoxvirus, can result in a smallpox-like disease. 1 Predominant signs and symptoms include skin rash, fever, adenopathy, headache, and myalgias. Currently there is no specific treatment except for symptomatic management. We present a rare case of monkeypox in a patient with HIV presenting with conjunctivitis.A 42-year-old man presented with left-eye lacrimation, pain, and photophobia for the past 6 days. On the fifth day since the symptoms started, the patient reported maculopapular lesions on his face (Figure 1) and foot. The patient also had fever and painful cervical adenopathy. He was HIV positive. He denied any recent trip or contact with monkeypox cases. However, his boyfriend works in a sex club and had fever.

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