The discovery of angiotensin-I-converting enzyme 2 (ACE2) and a (pro)renin receptor has renewed interest in the physiology of the renin-angiotensin system (RAS). Through the ACE2/angiotensin-(1-7)/Mas counter-regulatory axis, ACE2 balances the vasoconstrictive, proliferative, fibrotic and proinflammatory effects of the ACE/angiotensin II/AT1 axis. The (pro)renin receptor system shows an angiotensin-dependent function related to increased generation of angiotensin I, and an angiotensin-independent aspect related to intracellular signalling. Activation of ACE2 and inhibition of ACE and renin have been at the core of the RAS regulation. The aim of this review is to discuss the biochemistry and biological functions of ACE, ACE2 and renin within and beyond the RAS, and thus provide a perspective for future bioactives from natural plant and/or food resources related to the three proteases.
An oscillation with a period of about 2100–2500 years, the Hallstatt cycle, is found in cosmogenic radioisotopes (14C and 10Be) and in paleoclimate records throughout the Holocene. This oscillation is typically associated with solar variations, but its primary physical origin remains uncertain. Herein we show strong evidences for an astronomical origin of this cycle. Namely, this oscillation is coherent to a repeating pattern in the periodic revolution of the planets around the Sun: the major stable resonance involving the four Jovian planets - Jupiter, Saturn, Uranus and Neptune - which has a period of about p = 2318 years. Inspired by the Milankovi´ c’s theory of an astronomical origin of the glacial cycles, we test whether the Hallstatt cycle could derive from the rhythmic variation of the circularity of the solar system assuming that this dynamics could eventually modulate the solar wind and, consequently, the incoming cosmic ray flux and/or the interplanetary/cosmic dust concentration around the Earth-Moon system. The orbit of the planetary mass center (PMC) relative to the Sun was used as a proxy.We analyzed how the instantaneous eccentricity vector of this virtual orbit varies from 13,000 BCE to 17,000 CE. We found that it undergoes kind of pulsations as it clearly presents rhythmic contraction and expansion patterns with a 2318 year period together with a number of already known faster oscillations associated to the planetary orbital stable resonances, which are theoretically calculated. These periods include a quasi 20-year oscillation, a quasi 60-year oscillation, the 82-97 year Gleissberg oscillation and the 159-185 year Jose oscillation. There exists a quasi p/2 phase shift between the 2100–2500 year oscillation found in the 14C record and that of the calculated eccentricity function. Namely, at the Hallstatt-cycle time scale, a larger production of radionucleotide particles occurs while the Sun-PMC orbit evolves from more elliptical shapes (e ≈ 0.598) to more circular ones (e ≈ 0.590), that is while the orbital system is slowly imploding or bursting inward; a smaller production of radionucleotide particles occurs while the Sun-PMC orbit evolves from more circular shapes (e ≈ 0.590) to a more elliptical ones (e ≈ 0.598), that is while the orbital system is slowly exploding or bursting outward. Since at this timescale the PMC eccentricity variation is relatively small (e = 0.594 ± 0.004), the physical origin of the astronomical 2318 year cycle is better identified and distinguished from faster orbital oscillations by the times it takes the PMC to make pericycles and apocycles around the Sun and the times it takes to move from minimum to maximum distance from the Sun within those arcs. These particular proxies reveal a macroscopic 2318 year period oscillation, together with other three stable outer planets orbital resonances with periods of 159, 171 and 185 years. This 2318 year oscillation is found to be spectrally coherent with the D14C Holocene record with a statistical confidence above 95%, as deter...
Purpose A life cycle assessment was conducted to determine a baseline for environmental impacts of cheddar and mozzarella cheese consumption. Product loss/waste, as well as consumer transport and storage, is included. The study scope was from cradle-to-grave with particular emphasis on unit operations under the control of typical cheese-processing plants. Methods SimaPro© 7.3 (PRé Consultants, The Netherlands, 2013) was used as the primary modeling software. The ecoinvent life cycle inventory database was used for background unit processes (Frischknecht and Rebitzer, J Cleaner Prod 13(13-14): [1337][1338][1339][1340][1341][1342][1343] 2005), modified to incorporate US electricity (EarthShift 2012). Operational data was collected from 17 cheese-manufacturing plants representing 24 % of mozzarella production and 38 % of cheddar production in the USA. Incoming raw milk, cream, or dry milk solids were allocated to coproducts by mass of milk solids. Plant-level engineering assessments of allocation fractions were adopted for major inputs such as electricity, natural gas, and chemicals. Revenue-based allocation was applied for the remaining in-plant processes. Results and discussion Greenhouse gas (GHG) emissions are of significant interest. For cheddar, as sold at retail (63.2 % milk solids), the carbon footprint using the IPCC 2007 factors is 8.60 kg CO 2 e/kg cheese consumed with a 95 % confidence interval (CI) of 5.86-12.2 kg CO 2 e/kg. For mozzarella, as sold at retail (51.4 % milk solids), the carbon footprint is 7.28 kg CO 2 e/kg mozzarella consumed, with a 95 % CI of 5.13-9.89 kg CO 2 e/kg. Normalization of the results based on the IMPACT 2002+ life cycle impact assessment (LCIA) framework suggests that nutrient emissions from both the farm and manufacturing facility wastewater treatment represent the most significant relative impacts across multiple environmental midpoint indicators. Raw milk is the major contributor to most impact categories; thus, efforts to reduce milk/cheese loss across the supply chain are important. Conclusions On-farm mitigation efforts around enteric methane, manure management, phosphorus and nitrogen runoff, and pesticides used on crops and livestock can also significantly reduce impacts. Water-related impacts such as depletion and eutrophication can be considered resource management issues-specifically of water quantity and nutrients. Thus, all opportunities for water conservation should be evaluated, and cheese manufacturers, while not having direct control over crop irrigation, the largest water consumption activity, can investigate the water use efficiency of the milk they procure. The regionalized normalization, based on annual US per capita cheese consumption, showed that eutrophication represents the largest relative impact driven by phosphorus runoff from agricultural fields and emissions associated with whey-processing wastewater. Therefore, incorporating best practices around phosphorous and nitrogen management could yield improvements.
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