Background. Vibration Therapy (VT) has been attributed to the reflex activation of alpha motor neurons resulting in improved neuromuscular performance (NP). Objective. Changes in muscular performance after VT was evaluated based on MVC grip strength, grip endurance time at 50% MVC and EMG activities of forearm muscles, viz., flexor digitorum superficialis (FDS); flexor carpi ulnaris (FCU); extensor carpi radialis brevis (ECRB); and extensor carpi ulnaris (ECU) in supine posture. Methods. Eight VT protocols (based on the different combinations of vibration frequency (35 and 45 Hz), amplitude (3 g ± 0.5 g and 9 g ± 0.5 g) and exposure duration (30 and 60 seconds)) were given to the participants for 4 days. Participants were from two groups (56/group): persons with a sedentary lifestyle (SL) and a group of construction workers (CW). Results. VT protocols had a significant effect on MVC grip strength (p < 0.001), grip endurance time (p < 0.05), % normalized EMG rms (p < 0.05) and neuromuscular efficiency (NME) (p < 0.001) in all muscles for both groups. VT protocol E (45 Hz, 3 ± 0.5 g, 30 s) had more positive effects on MVC grip strength for CW and less positive for SL. However, VT protocol B (35 Hz, 3 ± 0.5 g, 60 s) had more positive effects on CW grip endurance time. In addition, the highest increase in NME was found in FDS muscle for VT protocol H (45 Hz, 9 ± 0.5 g, 60 s) (212.8%) in CW and 78.55% in SL. Conclusions. VT protocols B, E, and H may be applied to workers involved in the construction industry. These interventions may improve NME, MVC grip strength, and grip endurance time. Findings may be used to form a clinical VT protocol for patients with weak muscle performances.