SummarySchistosomiasis remains to be the most common fi brotic disease resulting from infl ammation and deposition of scar tissue around trapped parasitic eggs in the liver. Though chemotherapy eradicates matured worms effi ciently and prevents the accumulation of schistosome eggs, fewer effective drugs are directed to reverse the present hepatic fi brosis. Therefore, treatment targeting hepatic fi brosis associated with schistosomiasis remains a challenging proposition. The present study was designed to investigate the potential complementary schistosomicidal and hepatoprotective activities of the methanol extract of Capparis spinosa L. (C. spinosa) with or without praziquantel (PZQ) and compare results with silymarin (Milk thistle), a known hepatoprotective and antifi brotic agent, on induced liver fi brosis by experimental Schistosoma mansoni (S. mansoni) infection. Total polyphenols in the extract were determined using colorimetric assay. C. spinosa L. caused a partial decrease in worm burden; a statistically signifi cant reduction in hepatic and intestinal tissue egg load, what was associated histopathologically with decreasing in both the number and diameter of granulomas, as well as restoring serum aminotransferases (AST & ALT), alkaline phosphatase (ALP) and improving liver albumin synthesis. The best results were obtained in the group of mice treated with C. spinosa L. and PZQ together. Quantitative estimation of total polyphenols content using colorimetric assay showed that C. spinosa L. leaves contain higher concentration of polyphenolic compounds than fruits. It was concluded that C. spinosa L. has a promising hepatoprotective and antifi brotic properties and could be introduced as a safe and effective therapeutic tool with PZQ in the treatment of schistosomal liver fi brosis. Nevertheless further studies on the mechanism of action of C. spinosa L. in chronic liver diseases may shed light on developing therapeutic methods in clinical practice.