A new microemulsions system of curcumin (CUR-MEs) was successfully developed to improve the solubility and bioavailability of curcumin. Several formulations of the microemulsions system were prepared and evaluated using different ratios of oils, surfactants, and co-surfactants (S&CoS). The optimal formulation, which consists of Capryol 90 (oil), Cremophor RH40 (surfactant), and Transcutol P aqueous solution (co-surfactant), could enhance the solubility of curcumin up to 32.5 mg/mL. The pharmacokinetic study of microemulsions was performed in rats compared to the corresponding suspension. The stability of microemulsions after dilution was excellence. Microemulsions have significantly increased the C(max) and area under the curve (AUC) in comparison to that in suspension (p < 0.05). The relative bioavailability of curcumin in microemulsions was 22.6-fold higher than that in suspension. The results indicated that the CUR-MEs could be used as an effective formulation for enhancing the oral bioavailability of curcumin.

No abstract

No abstract

Abstract. The objective of this study was to improve the solubility and bioavailability of curcumin by a new curcumin dripping pills (Cur-DPs) formulation using melt mixing methods. The optimal formulation consisted of Polyethoxylated 40 hydrogenated castor oil (Cremophor RH40), Poloxamer 188, and Polyethylene glycol 4000 (PEG 4000). Differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), and Fourier-transform infrared spectroscopy (FT-IR) were used to verify the forming of CurDPs. All the physical characterization information proved the formation of Cur-DPs, and the results demonstrated the superiority of the dripping pills in dissolution rates. The pharmacokinetic study of CurDPs was performed in rats compared to the pure curcumin suspension. The oral bioavailability of poorly water-soluble curcumin was successfully improved by CUR-DPs. And the stability of prepared Cur-DP was also in a good state in 3 months. These results identified the Cur-DPs was an effective new approach for pharmaceutical application.

Epitaxial growth and strain relaxation of Ba Ti O 3 thin films on Sr Ti O 3 buffered (001) Si by molecular beam epitaxy J.High quality epitaxial MgO thin films have been grown on Si ͑001͒ wafers by molecular beam epitaxy using SrTiO 3 ͑STO͒ as a buffer layer. The STO buffer layer reduces both the large lattice mismatch of 23% and the large thermal mismatch of 520% between MgO and Si. X-ray diffraction ͑XRD͒ measurements indicate that the MgO film grown on the STO buffered Si is epitaxial with MgO ͑002͒ ʈ Si ͑004͒ and MgO ͓110͔ ʈ Si ͓002͔. The full width at half maximum ͑FWHM͒ of MgO ͑002͒ rocking curve width ⌬ is 0.30°͑out-of-plane͒, and the FWHM of MgO ͑202͒ angle scan width ⌬ is 0.34°͑in-plane͒ for a 155 nm thick film. Strain relaxation and growth mechanisms of the MgO film on Si were studied by in situ reflection high-energy electron diffraction ͑RHEED͒ analysis in combination with XRD and atomic force microscopy. The results indicate that the MgO first forms a pseudomorphic wetting layer and subsequently undergoes a Stranski-Krastanov transition to form three-dimensional coherent islands to relieve misfit strain. A decrease in the width of the RHEED spots with increasing MgO thickness is observed that is attributed to reduction of coherency strain. A smooth surface redevelops once MgO growth continues, which is attributed to island coalescence.