This descriptive cross sectional study was carried out in the department of paediatrics, Mymensingh Medical College Hospital from March 2006 to December 2006. This study was performed on 100 consecutive asphyxiated newborns who were admitted in Mymensingh Medical College Hospital during the study period. Among them, 50 babies were preterm and 50 babies were full term with moderate to severe perinatal asphyxia. Full term (>37 weeks of gestation) and preterm (<37 weeks of gestation) newborn babies with perinatal asphyxia was taken as case in inclusion criteria. Among the preterm babies, highest number 23(46%) were in the age group o/ 34-36 weeks of gestational age and among the term babies, highest number 24(48%) were in the age group of 39-40 weeks of gestational age. This study shows that 39% mothers had prolong obstructed labour, 21% had premature rupture membrane and 17% had pre-eclamptic toxaemia during pregnancy,. Convulsion 66%, poor primitive reflexes 52%, cyanosis 49% pallor 32%, respiratory distress 32% and apnoic spells 26% were the common presentations of asphyxiated babies. Out of 50 preterm asphyxiated newborn, one showed periventricular leukomalacia, two IVH and two ventricular dilatation. In the present study abnormal sonogram were detected in ten term babies. Two cases showed features of cerebral oedema and eight cases showed mild to moderate ventriculomegaly together with several subcortical cystic lesions of varying size. In case of comparison, eight cases had ventricular dilatation in term babies while 2 cases had in preterm babies. None of the term babies had ventricular haemorrhage but 2 had in preterm babies. Only, one preterm baby had periventricular leukomalacia but none among the term babies. There were 2 cases of cerebral oedema in term babies but none in preterm babies. Thus ultrasonography helps early recognition of intracranial abnormalities in asphyxiated newborns. So prognosis may be assessed, complication may be anticipated and appropriate management plan can be designed. DOI: http://dx.doi.org/10.3329/bmj.v41i3.18956 Bangladesh Medical Journal 2012 Vol.41(3): 33-37

Objective: To compare the frequency of low APGAR scores in babies born to normotensive patients with asymptomatic hyperuricemia with those without hyperuricemia.Study Design: Cohort Study.Place and Duration: This study was conducted at the department of gynaecology/obstetrics, Liaquat National Hospital Karachi from January 2015 to January 2016.Materials and Methods: The sample size was calculated by using openepic.com version 2, an open-source calculator. The sample size was calculated to be 165 in each group, which made a total of 330 patients. Non-probability consecutive sampling was chosen as the sampling technique. All normotensive pregnant females with blood pressure of less than 130/90 between 18 to 40 years of age, with singleton pregnancy at 37 weeks and beyond were included in the study. Normotensive pregnant females with hyperuricemia were the exposed group while normotensive pregnant females with normal uric acid levels were the non-exposed group. The exclusion criteria included patients with multiple gestations, medical disorders like gout, chronic renal failure, APLS, Rheumatoid Arthritis, etc, on anti-hypertensives and smokers. Fetal outcomes were assessed in all patients after delivery and a comparison of outcomes was made between two groups. Results: The study was designed to compare the frequencies of low APGAR scores in babies born to normotensive patients with asymptomatic hyperuricemia to those without hyperuricemia. The main outcome in group A i.e. exposed group was 29 babies with low APGAR score (<7) with 17.5% and in group B, which was non-exposed, 12 (7.57%) of babies had low APGAR score (<7). P-value came out to be 0.0010. The difference was statistically significant.Conclusion: It is concluded that there is a significant difference between the frequency of low APGAR scores in babies born to normotensive patients with hyperuricemia to those without hyperuricemia.