Mollusks are considered a source of nutritious food and their consumption has been increasing worldwide. However, the consumption of mollusks, mainly bivalves, has been considered responsible for numerous cases of foodborne diseases. This is related to their food intake, as they filter feed and consequently bioaccumulate toxic compounds. High hydrostatic pressure (HHP) is recognized as an efficient technology to control pathogenic and deteriorating microorganisms, with low damage to the sensorial and nutritional properties of foods. This review addresses the use of HHP on bivalve mollusks, based on recent works of relevance in this field.