Electronic poster abstractsfrom both sides of the bladder. The presence of SUA was also checked at the second (18-21 weeks) scan and after delivery by visual assessment of placenta. Concordance between first and second trimester findings was compared. Results: Prevalence of SUA was 0.92%. In 8.7% of cases the number of vessels in the cord was not possible to assess. Sensitivity, specificity, positive and negative predictive value for the finding in the first trimester were 92, 99.8, 79 and 99.9% respectively. In 31% of cases the fetus had associated malformations. With an ultrasound at 12-14 weeks most of the cases with significant fetal malformation were diagnosed. There was high concordance between the findings in the first and second trimester scan (coefficient of correlation 0.89). Conclusions: SUA is a useful marker for fetal malformation in the first trimester. It allows detection of a large number of cases with malformations before 20 weeks of gestation.The diagnosis of SUA at the first trimester scan is accurate and reproducible in the second trimester, so we could recommend to include its assessment into the protocol of 11-13 weeks scan. EP08.07Estimation of gestational age at 11 to 13 + 6 weeks of gestation using fetal biparietal diameter in a Korean population Objectives: To evaluate fetal biparietal diameter (BPD) between 11 and 13 + 6 weeks' gestation in pregnant Korean women after in vitro fertilisation (IVF), to construct reference charts for estimation of gestational age and to compare these charts with well-established standards. Methods: Data were retrospectively collected on 536 singleton Korean pregnancies conceived after IVF that underwent sonography between 11 and 13 + 6 weeks' gestation. The BPD was measured from the outer to the inner edge of the parietal bone in a transverse plane. Gestational age was calculated by adding 14 to the number of days between the date of oocyte retrieval and the date of the ultrasound scan. Results: We developed a new chart of BPD for the Korean population to estimate gestational age between 11 and 13 + 6 weeks. The BPD of Korean pregnancies was similar to previously described estimations at 11 weeks of gestation, but tended to be greater with advancing gestational age than those predicted by the formulas of Selbing and Kjessler. The best-fit equation for estimation of gestational age from BPD was GA (day) = 83.3571 − (0.8742 × BPD) + (0.0498 × BPD 2 ); and SD = −0.09850 + (0.08659 × BPD). Conclusions:The described chart may improve the accuracy of estimating GA in Korean pregnant women in the late first trimester.Supporting information can be found in the online version of this abstract Objectives: Assessing the angiogenic factors levels and the Doppler parameters in healthy controls and fetal growth restriction (FGR). Methods: This case-control study included 66 patients with diagnosis of FGR and 64 healthy pregnancies at 24-41 weeks of gestation. For both groups, maternal circulating concentrations of angiogenic factors of soluble fms-like tyrosine kinase-...

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Objectives: To investigate the levels and distribution of uterine artery pulsatility index (PI) in the first trimester of Chinese pregnancies and compare them to that predicted by the Fetal Medicine Foundation (FMF). Methods: Sonographers, with an FMF certificate of competence to perform uterine artery Doppler waveform assessment, prospectively assessed and measured the left and right uterine artery PI in Hong Kong Chinese pregnant women having a singleton pregnancy whilst performing first trimester screening for aneuploidies in April 2013. The measurements were performed by transabdominal ultrasound imaging and in accordance with FMF recommended practice. The lower of the two PI (L-PI) was used for analysis. The L-PI were converted into multiples of the expected median (MoM) corrected for fetal crown rump length, maternal age and body mass index using linear regression model published by the FMF. The results of the uterine artery PI assessment were not given to the women and did not influence the subsequent pregnancy management. Results: 320 Women had a first trimester Doppler uterine artery assessment. The median (range) L-PI, CRL, maternal age at EDD, and BMI were 1.7 (0.6-3.6), 59.3 mm (42-79), 32.3 years (21.3-44.2) and 21.4 Kg/m2 (15.9-33.2) respectively. After correcting for maternal factors using the FMF expected L-PI the median L-PI MoM was 1.16 (95% CI 1.13 to 1.23) and the standard deviation of the log10 L-PI MoM was 0.12. Linear regression analysis confirmed that Log10 L-PI was significantly associated with CRL but not maternal age or BMI in our cohort. Conclusions: Our data and analysis would indicate that using the FMF published expected L-PI in normal pregnancies did not result L-PI MoM centered on 1 MoM and if adopted would result in an increased screen positive rate in our population. Objectives: To investigate the role of maternal renal interlobar vein Doppler during the first trimester (11-13 + 6 weeks) for preeclampsia (PE) prediction. We are looking for Doppler markers to add to a multiparametric PE prediction model previously described (maternal history, MAP, uterine artery Doppler) in order to improve the detection rate and/or lower the false-positive rate. Methods: Prospective study with singleton pregnancies examined between 11-13 + 6 weeks of gestation, presenting consecutively for antenatal care in a secondary hospital. We collected data from maternal history and MAP was measured. Uterine artery and interlobar renal vein Doppler were performed using standardized technique in 90 pregnant women for the same examiner. Then mean RIVI (renal interlobar vein impedance) was calculated as Vmax-Vmin/Vmax. Satisfactory renal flow velocity waveforms and obstetric and perinatal outcomes were achieved in 82 women. Results: The mean maternal age was 27 years (range 13-42 years) and the mean gestational was 12 weeks (range 11-13 + 6 weeks). In a total of 82 patients, 6 (7,3%) developed PE (4 late-onset and 2 early-onset). Objectives: The aim of this study is to validate the Fetal Medicine Foundation ...