The robustness of a new single cylinder pressure sensor concept is experimentally demonstrated on a six cylinder heavy-duty Diesel engine. Using a single cylinder pressure sensor and a crank angle sensor, this single cylinder pressure sensor concept estimates the in-cylinder pressure traces in the remaining cylinders by applying a realtime, flexible crankshaft model combined with an adaptation algorithm. The single cylinder pressure sensor concept is implemented on CPU/FPGA based hardware. For steady-state engine operating conditions, the added value of the adaptation algorithm is demonstrated for cases in which a fuel quantity change or start of injection change is applied in a single, non-instrumented cylinder. It is shown that for steady state and transient engine conditions, the cylinder pressure traces and corresponding combustion parameters, IMEP, PMAX, and CA50, can be estimated with 1.