Introduction:Patients with chronic renal disease are at risk for dyspnea, which can have a negative impact on their quality of life. The current study aims to investigate the influence of breathing exercise on respiratory parameters in hemodialysis patients due to a lack of agreement on the efficacy of breathing exercise in the respiratory status of hemodialysis patients.Method: Participants were randomly assigned to one of two groups in this single-blind clinical investigation (intervention and control). Under the supervision of a nurse, the intervention group practiced breathing interventions (deep and slow breathing) for eight sessions over the course of a month. Data was collected using two questionnaires (demographic and respiratory parameter checklist).Results: There was a significant change (P=0.000) between the pre-and post-scores of the respiratory score in the intervention and control groups. Conclusion:Because breathing intervention is beneficial in lowering dyspnea and improving respiratory parameters, nurses should consider using it as an appropriate therapy for these patients due to its simplicity and low cost.