Remote monitoring is an important technical way to assure the key equipment to run properly and safely. In the paper, a remote monitoring system based on GPRS wireless communication was developed for large-scale equipments. The architecture of the system was given. The key techniques of the system design, including the remote data transmission, remote monitoring and fault diagnosis techniques were analyzed. Furthermore, the hardware and software design of Data Transmission Unit (DTU) was introduced in detail. And the functional modules of the remote monitoring service system were presented. The system provides an effective way to realize remote monitoring and fault diagnosis for large-scale equipments.