Synthesis and Antimicrobial Activity of Novel Aminopyrimidinedione and Aminothiazolidinedione Derivatives.--(EL-ABLAK, F. Z.; ETMAN, H. A.; METWALLY, M. A.; AMER, F. A.; Pharmazie 50 (1995) 3, 222-224; Dep. Chem., Fac. Sci., Univ., Mansoura, Egypt; EN)

Michael addition of 1,5‐diaryl‐2,3‐dioxopyrrolidine derivatives with α‐cyanocinnamonitriles and ethyl α‐cyanocinnamates afforded 4H‐pyrano[2,3‐c]pyrrole derivatives in the presence of sodium ethoxide. Under the same reaction condition, the ylidenes of 1,5‐diaryl‐2,3‐dioxopyrrolidine were reacted with malononitrile or ethyl cyanoacetate to give isoindole derivatives; however, pyrrolo[3,4‐b]pyridine derivatives were formed when cyanoacetamide was used. Moreover, pyrrolo[3,4‐d]pyrimidine derivatives were synthesized by treating 4‐benzylidene‐1,5‐diphenyl‐2,3‐dioxopyrrolidine with urea and/or thiourea under basic conditions. The structures of all the new synthesized compounds were confirmed by elemental analysis, IR and NMR spectra.

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