By combining intravoxel incoherent motion (IVIM) and diffusion tensor imaging (DTI) we introduce a new diffusion model called intravoxel oriented flow (IVOF) that accounts for anisotropy of diffusion and the flow-related signal. An IVOF model using a simplified apparent flow fraction tensor (IVOFf ) is applied to diffusion-weighted imaging of human kidneys. The kidneys of 13 healthy volunteers were examined on a 3 T scanner. Diffusion-weighted images were acquired with six b values between 0 and 800 s/mm(2) and 30 diffusion directions. Diffusivity and flow fraction were calculated for different diffusion models. The Akaike information criterion was used to compare the model fit of the proposed IVOFf model to IVIM and DTI. In the majority of voxels the proposed IVOFf model with a simplified apparent flow fraction tensor performs better than IVIM and DTI. Mean diffusivity is significantly higher in DTI compared with models that account for the flow-related signal. The fractional anisotropy of diffusion is significantly reduced when flow fraction is considered to be anisotropic. Anisotropy of the apparent flow fraction tensor is significantly higher in the renal medulla than in the cortex region. The IVOFf model describes diffusion-weighted data in the human kidney more accurately than IVIM or DTI. The apparent flow fraction in the kidney proved to be anisotropic.

DWI with IVIM reliably visualises synovitis of the knee joint. Perfusion fraction maps differentiate thickened synovium from joint effusion and hence increase diagnostic confidence.

Industrial high-precision 3D Printing (HP3DP) via two-photon absorption (TPA) provides freedom in design for the fabrication of novel products that are not feasible with conventional techniques. Up to now, 2PP-fabrication has only been used for structures on the micrometer scale due to limited traveling ranges of the translation stages and the field-of-view (FoV) of microscope objectives (diameters below 0.5 mm). For industrial applications, not only high throughput but also scalability in size is essential. For this purpose, this contribution gives insights into different manufacturing strategies composed of varying exposure modes, fabrication modes, and structuring modes, which enable the generation of large-scale optical elements without relying on stitching. With strategies like stage-only mode or synchronized movement of galvoscanners and translation stages, optical elements with several millimeters in diameter and freeform shape can be fabricated with optical surface quality.

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