There are many gender differences relating to mental health issues and they concern all aspects: diagnosis, treatment and incidence. No research has been conducted to evaluates the role of metacognition on the basis of gender and its relation to other psychological constructs. This study had two primary goals. The first was to compare metacognitions by gender. The second goal was to explore the relations among the constructs of metacognitions, anxiety, depression, pathological worry, and obsessive-compulsive symptoms in two groups. Sixty-four participants (32 men and 32 women) took part in this study; they were assessed with the MCQ-30, STAI, BDI, PSWQ, and PADUA Inventory. T-test results for two independent samples for MCQ-30 did not reveal differences between gender. Results of correlational analysis found significant relations between dysfunctional metacognitive beliefs and other constructs on the basis of gender. In conclusion, results of this study point out that gender differences can play an important role in the clinical efficacy of treatments.