Purpose Talented people with interpersonal skills and competencies are pivotal for creating knowledge, innovation and organizational effectiveness, contributing to local development. In this regard, the quality of life is a critical factor in attracting and retaining talented people in any region. This study aims to analyze talents’ perception of the quality of life in an urban innovation ecosystem. This study considers talents to be the students from Science, Technology, Engineering and Mathematics programs. Design/methodology/approach This study analyzes 263 students from three of the country’s most important universities located in the city of Porto Alegre in southern Brazil. This study examines the data using principal component analysis and cluster techniques. Findings The results indicate five clusters. The “Love for the city” and the “Mixed” ones portray high levels of a sense of belonging to the city, but differ, for example, in their perception on city infrastructure. Conversely, both the “Worried about education” and the “Worried about commercial services” ones express low levels of a sense of belonging in the city. The “Security” cluster portrays the highest level on security issues in the city. The cluster analyses provide detailed information on the factors valued by talents in urban innovation ecosystems. Originality/value To date, to the best of the authors’ knowledge, this study is the first that uses cluster techniques to measure talents’ perception of the quality of life in an urban innovation ecosystem. The findings contribute to mapping talents’ perception and building profiles which may support the development of policies and programs to attract and retain qualified people in innovation ecosystems.