OBJECTIVE:To analyze the socioeconomic background and its relationship with spatial distribution of mortality due to violence. METHODS:Ecological study conducted to explore the space distribution of mortality due to violence in the city of Vitória, Southeastern Brazil, between 2000 and 2003, based on population and socioeconomic information. Mortality data were correlated with information on victim's place of residence, type of violence, gender, and skin color. Data were analyzed using space average, odds ratio, and cluster analysis. RESULTS:There were reported 828 deaths due to violence during the study period, accounting for 17% of all deaths in the city. Of these, 72% were homicides, 21.8% traffi c accidents, and 6% suicides. Violence victims were mostly young black males, living in poorer areas of the city. In contrast, as for suicide and traffi c accidents, the victims were older white females living in the wealthiest area of the city. CONCLUSIONS:The study showed that violence is a phenomenon occurring in all socioeconomic levels but black people at the lowest level are more likely to die from homicides while white well-off people are more likely to die from suicide and traffi c accidents.

BackgroundA paradoxical immunologic response (PIR) to Highly Active Antiretroviral Therapy (HAART), defined as viral suppression without CD4 cell-count improvement, has been reported in the literature as 8 to 42%, around 15% in most instances. The present study aims to determine, in a cohort of HIV infected patients in Brazil, what factors were independently associated with such a discordant response to HAART.MethodsA case-control study (1:4) matched by gender was conducted among 934 HIV infected patients on HAART in Brazil. Cases: patients with PIR, defined as CD4 < 350 cells/mm3 (hazard ratio for AIDS or death of at least 8.5) and undetectable HIV viral load on HAART for at least one year. Controls: similar to cases, but with CD4 counts ≥ 350 cells/mm3. Eligibility criteria were applied. Data were collected from medical records using a standardized form. Variables were introduced in a hierarchical logistic regression model if a p-value < 0.1 was determined in a bivariate analysis.ResultsAmong 934 patients, 39 cases and 160 controls were consecutively selected. Factors associated with PIR in the logistic regression model were: total time in use of HAART (OR 0.981; CI 95%: 0.96-0.99), nadir CD4-count (OR 0.985; CI 95%: 0.97-0.99), and time of undetectable HIV viral load (OR 0.969; CI 95%: 0.94-0.99).ConclusionsPIR seems to be related to a delay in the management of immunodeficient patients, as shown by its negative association with nadir CD4-count. Strategies should be implemented to avoid such a delay and improve the adherence to HAART as a way to implement concordant responses.

SUMMARYSome patients under antiretroviral therapy (ART) do not reach immune recovery when the viral load becomes undetectable. This is called discordant immunologic and virologic responses. Its prevalence varies between 8% and 24%. This study describes its prevalence and the characteristics of the affected subjects in the outpatient clinic of a Brazilian specialized-care center. Of 934 patients on ART, 536 had undetectable viral loads. Prevalence was 51/536 or 9% (95% confidence interval: 6.6% to 11.4%). Median age at the beginning of ART was 37 years (interquartile range -IQR: 31 to 45). Male gender and mixed race predominated (76.5% and 47.1% respectively). AIDS-defining illnesses were absent at the beginning of ART in 60.8%. Fifty-one percent were taking protease inhibitors, 43.2% Efavirenz and 5.8% both. Median time on ART was 36 months (IQR: 17-81 months). Irregular treatment was recorded for 21.6%. ART had been modified for 63% prior to the study, and 15.7% had used monotherapy or double therapy. Median CD4 count was 255 cells/mm . Median viral load before ART was 4.7 log 10 copies/mL (IQR: 4.5-5.2). Discordant responders were not different from AIDS patients in general, but there was a high frequency of multiple schedules of treatment.