The nuclear hormone receptor peroxisome proliferator-activated receptor ␥ (PPAR␥ (NR1C3)) plays a central role in adipogenesis and is the molecular target for the thiazolidinedione (TZD) class of antidiabetic drugs. In a search for novel non-TZD ligands for PPAR␥, T0070907 was identified as a potent and selective PPAR␥ antagonist. With an apparent binding affinity (concentration at 50% inhibition of
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