A series of phthalimide analogs were synthesized by derivatization of phthalic anhydride, a highly toxic substance, using a ''one pot'' condensation reaction to a-amino acids. All phthaloyl amino acid derivatives presented anti-oral inflammatory activity, but compounds 2e and 2g were found to possess the best activities comparable to thalidomide. Most of the compounds effectively suppressed nitric oxide production in murine cells stimulated with lipopolysaccharide. Nphthaloyl amino acids did not exhibit any significant cytotoxicity in vitro when tested against tumor cells as well as a spleen cell culture of BALB/c mice. Compounds 2a, 2g, and 2h were able to inhibit TNF-a and IL-1b production by macrophages. At the same concentration, thalidomide did not exhibit significant inhibitory activity.

No abstract

Durante o levantamento de fungos anamórficos associados à folhas em decomposição de diferentes plantas na região semi-árida do Estado da Bahia, 23 espécies, pertencentes a 19 gêneros foram encontradas. Dessas, uma espécie constitui novo registro para a Bahia e três para o Brasil, respectivamente: Drechslera victoriae (F. Meehan & H.C. Murphy) Subram. & B.L. Jain, Ochroconis crassihumicola (Matsush.) de Hoog & Arx, Pyricularia caffera Matsush. e Tretopileus sphaerophorus (Berk & M.A. Curtis) Hughes & Deighton. Descrições, comentários e ilustrações são apresentados para essas espécies.

-(Cryptophiale and Cryptophialoidea (Conidial fungi) from Brazil and keys to the genera). During a survey of microfungi associated with dead leaves in the State of Bahia, Brazil, four species of Cryptophiale Piroz. and two species of Cryptophialoidea Kuthub. & Nawawi were found. Cryptophiale guadalcanalensis Matsush. and Cryptophialoidea fasciculata Kuthub. & Nawawi are new records for the neotropics, while C. ramosa Delg.-Rodr., J. Mena & Gené is a new record for South America. Descriptions, illustrations and geographical distribution of all the fungi are provided.

During a survey of the microfungi associated with dead leaves of native plants in the State of Bahia, two species of Speiropsis were found: S. pedatospora Tubaki and S. scopiformis Kuthub. & Nawawi. Descriptions, illustrations, comments, geographical distribution and a compared table with taxonomic characteristics of the Speiropsis species are present. S. pedatospora is the first record for Brazil.