Background: With the advent of Assisted Reproduction Technology, management of infertility amongst couples has remarkably evolved. Despite this great leap, with an increase in the rate of fertilization, few pregnancies progress until birth. The objective of this study was to compare the evolution of pregnancies obtained after IVF to those obtained naturally. Methodology:We carried out a descriptive cross-sectional study with retrospective and prospective data collection from August 1 st , 2016 to April 30, 2019. Our study had two groups of pregnant women, the spontaneous pregnancy group and the post-IVF pregnancy group. Sampling was consecutive and exhaustive. Sociodemographic, clinical and para-clinical variables were collected. The Chi-square and Fischer's exact tests were used to compare variables. The odds ratio was calculated to determine associations between variables. A p value of < 0.05 was considered significant.Results: A total of 350 pregnancies were included in the study which comprised of 250 spontaneous pregnancies and 100 pregnancies obtained after IVF. Women pregnant through IVF, had an increase in the probability of being; nulliparous (OR: 26.18;]; p=0.01), primiparous (OR: 1.8; CI [1.12-2.88]; p<0.01), having multiple pregnancies (OR: 4.95;]; p<0.01) and first trimester vaginal bleeding (OR: 16.72;]; p<0.01) as compared to spontaneous pregnancies. We also observed that IVF pregnancies were 3.31 times more likely to end in elective cesarean section at the time of delivery than spontaneous pregnancies (OR: 3.31;]; p<0.01). Some of the obstetric and neonatal complications we studied had a comparable risk between the two groups without statistical significance. Conclusion:IVF pregnancies have a higher risk of bleeding and miscarriage in the first trimester with a higher probability in resulting to an elective cesarean section at the time of delivery compared to spontaneous pregnancies.