The development of an efficient method
for the synthesis of polysubstituted
isoindolinones from 1,3-dicarbonyl Ugi-4CR adducts, employing an aromatic
radical cyclization process promoted by tetrabutylammonium persulfate
and 2,2,6,6-tetramethyl-1-piperidine 1-oxyl (TEMPO), is described.
The protocol allowed the construction of a library of isoindolinones
bearing a congested carbon in good to excellent yields under mild
conditions and in short reaction times.
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