To cite this version:Manoela M. Manova, Assena Stoimenova, Fabrice Clerfeuille, Guenka I. Petrova. Impact of generic competition on market share and prices of cardiovascular medicines on the Bulgarian pharmaceutical market. Journal of Public Health, Springer Verlag, 2010, 19 (1) Abstract: Background During the last three decades a tremendous progress has been made in the discovery and development of a lot of new molecules in many pharmaceutical areas. These families of real innovative treatment comprise of "originator" molecules (first molecule released, which can be under patent or with expired patent), as well "generic" version of those originator molecules, whose patent has expired. Usually the patent expires 15 to 20 years after the creation of the originator molecule.Main objective This research focuses on the effects of the arrival of generic and or therapeutic competitors on the market, in terms of impacts on the market share and prices. Methodology Between 2005 and 2007 we follow three classes of medicinal products in the cardiovascular area:ACE inhibitors, sartans and statins. They have been studied on the Bulgarian market because there is no regulation in the country stimulating the generic market. The official database of the Bulgarian Health Insurance Fund was used to test our two hypothesis concerning the impact of the generics on market share and prices. To test our hypothesis a t-test analysis, Kolmogorov Smirnov, one and two way ANOVA analyses were performed. Results Our results confirm that the generic competition, in general, changes the market. These changes decrease the medicines prices. The generic competition is not regulatory supported in the country and this fact could influence negatively our study because it does not correspond to the world tendencies. Furthermore our results confirm that the creation of sustainable generic pharmaceutical market requires active regulatory and marketing measures at all levels including incentives for manufactures, physicians and dispensers.
Do client ' s age, gender or income affect how they may benefi t from certain services? Is the classifi cation of a service into one of the four categories of the tetra-class model, fi xed or, for example, linked to the length of time a customer has been a client or their geographical proximity? This study examines how the contribution of certain services to customer satisfaction changes in reference to his age, gender and income. Without questioning the suitability of the tetra-class model for classifying services, the authors have studied the nature of the changes in categories of services for three client-based variables and two variables linked to the service relationship. The results indicate that there are degrees of variability that alter in importance from one client segment to another and also with respect to the particular service under consideration.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.