This study was conducted to determine the distribution of the single nucleotide polymorphism (SNP) at position-1082 of the proximal promoter region of the interleukin (IL)-10 gene and its association with hepatitis virus co-infection in Indonesian Javanese human immunodeficiency virus (HIV)-infected patients. Methods: Blood samples were collected from 156 Indonesian Javanese HIV-infected patients; tested with serological and molecular assays for hepatitis B virus (HBV), hepatitis C virus (HCV), and hepatitis D virus (HDV); and subjected to SNP-1082 G/A polymorphism analysis. Results: Hepatitis B surface antigen (HBsAg) (+)/HBV DNA (+), HBsAg (-)/HBV DNA (+), anti-HCV antibodies (+)/HCV RNA (+), and anti-HCV antibodies (-)/HCV RNA (+) were detected from all of HIV-infected individuals at rates of 3.8% (6/156), 0.6% (1/156), 16.0% (25/156), and 11.5% (18/156), respectively. The frequencies of-1082 GG,-1082 GA, and-1082 AA were 14.7% (23/156), 60.3% (94/156), and 25% (39/156), respectively. HBV co-infection was found only in-1082 A allele carriers, and these patients also showed higher rates of HCV co-infection (odds ratio: 2.24, 95% confidence interval: 1.22-4.10, P=0.009). Conclusion: The-1082 A allele was associated with HBV and HCV co-infection in Indonesian Javanese HIV patients.