The 35 Community Health Centers in Depok City have limited resources and other duties besides serving patients. This limitation makes the Community Health Centers difficult to comply with the regulation of Regulation of Environmental and Forestry Ministry Number 56 Year 2015 on “Procedures and Technical Requirement of Hazardous Waste Management from Healthcare Facilities”, therefore there is need for adjustments and appropriate decision making in hazardous waste management, which can be done using Analytical Hierarchy Process (AHP) methods. AHP methods use 3 principles, which is hierarchy making, priority determination, and consistency ratio. The objective of this research is to choose the most optimal alternative for hazardous medical waste management, starting from reducing, sorting, storing, transporting, treatment, until burial. After conducting pair comparison from all respondent, the data processing is done using Expert Choice 11 software. This software helps in choosing alternatives via many criteria by inputting the comparison value from each respondent and display the priority value from each alternatives. The chosen alternative is as follows: reducing wasteby a good housekeeping, sorting phase with two containers or plastic bags, storing phase with freezer as described in Regulation of Environmental and Forestry Ministry Number 56 Year 2015, transportation phase using closed truck, off-site treatment, and burialusing secure landfill.