BACKGROUND: Many factors can influence the occurrence of dermatitis; this factor is divided into two, namely exogenous and endogenous factors. Fishermen are jobs that are susceptible to disease in dermatitis, especially contact dermatitis in the small island. AIM: This study aimed to determine the factors associated with the incidence of contact dermatitis in fishermen on the Spermonde islands. METHODS: This study was an observational analytic study using a cross-sectional design study. This research was conducted on Lae-Lae, Barrang Lompo, and Lumu-Lumu Island in 2019. Samples in this study were 110 fishermen obtained using Accidental sampling techniques. Data collection is using research instruments. RESULTS: Data analysis performed was univariate and bivariate analysis with a Chi-square test. Based on the results of the study, the research variables related to factors affecting contact dermatitis in fishermen in the Spermonde Islands were a history of skin diseases (p = 0.000), use of PPE (p = 0.000), personal hygiene (p = 0.000), and working period (p = 0.003) while unrelated factors are age (p = 0.373). CONCLUSION: Fishermen should pay more attention to four factors, namely the history of skin diseases, the use of PPE, hygiene, and work period, to avoid contact dermatitis.