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Sonchus oleraceus (Family: Asteraceae), Melia azedarach (Family: Meleaceae) and Citrus sinensis (Family: Rutaceae) were extracted in methanol and partitioned with hexane, ethyl acetate and n-butanol successively. Acetylcholine esterase (AChE) and protease activities were carried out by reported methods. Ethyl acetate and methanol extract of the selected plants were active in the enzyme assays. The extracts of S. oleraceus exhibited significant results in proteases assay with % inhibition 90.2 ± 1.4, IC50 = 23 ± 1 µg (methanol extract) and 71.1 ± 1.6, IC50 = 45 ± 2 µg (ethyl acetate extract). The solvent extracts of M. azedarach and C. sinensis showed moderate results in the enzyme inhibition assays. Among all the solvent extracts of the selected plants, hexane and n-butanol extracts showed very low response.

Introduction: Myocardial infarction (MI) is diagnosed by history of typical angina chest pain of prolonged duration along with ST segment elevation and ECG and or raised cardiac biomarkers.  Increased levels of CRP are associated with increased risk of HTN, DM and ischemic heart disease. Increased intake of trans fatty acids lead to increased levels of CRP, endothelial dysfunction and ischemic heart disease. Vessel wall is damaged after the inflammation and CRP is a marker of inflammation, so it can predict the cardiovascular disease. Objective: The objective of this study is to determine the level of high sensitivity CRP in MI patients with or without diabetes mellitus. Materials and methods: Total 60 patients were enrolled in the study. Patients having age from 40 to 70 years, diabetic patients and non-diabetic (male) and patients with acute myocardial infarcted patients were included. Patients having heart disease other than MI, patients less than 40 years were excluded. Level of high sensitivity CRP of patients of MI was analyzed by using chemiluminescence technique. High sensitivity CRP was analyzed quantitatively. Results: In this study 60 individuals with AMI were divided into two groups based on presence(n=30) 50% and absence (n=30) 50% of diabetes mellitus. The mean age of the population was 58.32 ± 11.24 years. Levels of high sensitivity CRP were distributed in four groups, the first group includes hsCRP < 10 mg/l, group-2 includes hsCRP 11-50 mg/l, group-3 comprises levels of hsCRP from 51-100mg/l and group-4 includes hsCRP level from 101-150mg/l. Both groups of AMI patients without and with DM had significantly higher levels of hsCRP as 40% and 31% patients have CRP level lies in group 3 and group 4 respectively. Moreover, the diabetic patients had higher levels of hsCRP as 50% of diabetic patients having levels of hsCRP fall in category of group 3 whereas only 13.3% non-diabetic patients have hsCRP falls in category of group 3. And this difference is statistically significant with the p value (p=0.007). Conclusion: The raised hsCRP is seen in AMI patients with history of diabetes, smoking and hypertension as compared to those AMI patients who had no previous history of all these risk factors.

e24141 Background: Ascites is a shared pathological manifestation of numerous diseases, the primary (81%) disease being hepatic cirrhosis. Ascites is termed “malignant” when it is associated with cancers. It can manifest as abdominal swelling, abdominal pain, nausea and vomiting, anorexia and fatigue. Our study aimed at identifying baseline characteristic in patients who present to our hospital with malignant ascites as the first sign of advanced stage cancers and the factors that can affect outcomes in such patients. Methods: This is a retrospective study which includes all the patients who had been diagnosed with malignant ascites at our institute between the years 2012 and 2016.The diagnosis was made either on the basis of cytological examination or medical imaging or both. Patients who were younger than 18 years and who developed ascites due to diseases other than malignancy were excluded from the study. A total of 150 patients were shortlisted using these criteria. Results: The mean age of the sample was 56.52 years with 101 (67%) of the patients being female, 54 (36%) diabetic, 55 (37%) hypertensive, 26 (52%) and 12 (8%) had ischemic heart disease. The most prevalent tumor reported was ovarian cancer 47 (31%) with the highest frequency of metastasis reported in the peritoneal region 34 (23%). Among symptoms, the most prevalent were abdominal distension 127 (85%), abdominal pain 99 (66%), 41 (27%) nausea, 44 (29%) vomiting and 32 (21%) reported weight change. Paracentesis was done in 139 (92%) for palliation of symptoms .Surgery was performed on 11 (7%) of the patients, whereas 70 (47%) of the patients were switched to chemotherapy with Carboplatin-Taxol constituting the major chemotherapeutic regimen. Majority 93 (62%) of the patients were discharged in a stable condition. The median survival following diagnosis of ascites was three months. Ovarian cancer favored longer survival while low serum albumin, low serum protein and liver metastases adversely affected survival. The independent prognostic factors for survival were cancer type, liver metastases and serum albumin. Conclusions: The identified independent prognostic factors should be used to select patients for multimodality therapy for adequate palliation.

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