Purpose: The current study was designed to examine the relationship between health anxiety, cyberchondria (its constructs), and metacognitive beliefs. In addition, it also evaluated the moderating role of metacognitive beliefs in this relationship. Design and Method: The present study used the purposive sampling technique to acquire a sample of (N = 500) adults, among them (N = 256) women and (N = 244) men, and the age of the sample ranged from 20 to 50 years. Short Health Anxiety Inventory, Cyberchondria Severity Scale, and Metacognitions Questionnaire–Health Anxiety were used to operationalize the present study variables. Findings: The descriptive statistics revealed that all instruments have good psychometric properties, as Cronbach’s alpha coefficients for all scales are ≥0.70. In addition to this, the Pearson correlation showed that all variables of the present study have a significant positive correlation with each other. Furthermore, the regression analysis described that health anxiety and metacognitive beliefs (biased thinking and beliefs about uncontrollable thoughts) were the significant positive predictors of cyberchondria. Moreover, moderation analysis showed that metacognitive beliefs significantly strengthened the association between health anxiety and cyberchondria and its constructs. Practical Implications: The present study will help medical practitioners to understand how metacognitive beliefs and health anxiety can cause an increase in cyberchondria. This will help them to design better treatment plans for people with cyberchondria.

Antimicrobial resistance and tolerance are natural phenomena that arose due to evolutionary adaptation of microorganisms against various xenobiotic agents. These adaptation mechanisms make the current treatment options challenging as it is increasingly difficult to treat a broad range of infections, associated biofilm formation, intracellular and host adapted microbes, as well as persister cells and microbes in protected niches. Therefore, novel strategies are needed to identify the most promising drug targets to overcome the existing hurdles in the treatment of infectious diseases. Furthermore, discovery of novel drug candidates is also much needed, as few novel antimicrobial drugs have been introduced in the last two decades. In this review, we focus on the strategies that may help in the development of innovative small molecules which can interfere with microbial resistance mechanisms. We also highlight the recent advances in optimization of growth media which mimic host conditions and genome scale molecular analyses of microbial response against antimicrobial agents. Furthermore, we discuss the identification of antibiofilm molecules and their mechanisms of action in the light of the distinct physiology and metabolism of biofilm cells. This review thus provides the most recent advances in host mimicking growth media for effective drug discovery and development of antimicrobial and antibiofilm agents.

Obesity is distinguished by unwanted and surplus accumulation of lipids in body principally in adipocytes. Inactive lifestyle and dietary irregularities are considered as premiers among a variety of obesogenic risk factors. Obesity is associated with variations in the concentration of trophic and tropic hormones from pituitary gland affecting different body parts and other endocrine glands including adrenal gland. Current study was design to explore the anti-obesity potential of cinnamon (Cinnamomum verum) against high sugar and high fat induced hyper-activity of pituitary-adrenal (PA) axis and obesity. Twenty-five healthy Wistar albino female rats were selected as model animal. Body weight, oral glucose tolerance test, serum cortisol, hematology and histopathological analysis were performed. The high sugar and high fat induced increase in body eight was decline by cinnamon administration. Hematological analysis revealed a significant decreased concentration of RBCs and hemoglobin and increased WBCs and platelet count following sub-acute exposure of high sugar and high fat changes were attenuated by cinnamon. High sugar and fat associated elevated serum cortisol was normalized after cinnamon exposure. Moreover, cinnamon protected the histopathological alterations following high sugar and fat administration, showed protective effects of Cinnamon against obesity associated dysregulation of PA axis and metabolic impairment.

Objective To assess the pattern of injuries in autopsy examination of road traffic accident cases at Peshawar. Materials and Methods A community-based descriptive cross-sectional study included a total of 94 candidates presented for autopsy at the forensic medicine department, Khyber medical college from 01st July 2020 to 30th June 2021. Results The age of the subjects ranged from 2-80 years with a mean age of 36.9 ± 20.7 years. 96.8 % of subjects were having multiple injuries whereas, 3.2% were having a single injury. Overall, 94 cases had a total number of 303 injuries, out of which 90.76% were small-sized, 7.92% were medium-sized and 1.32% were large-sized including all kinds of injuries. The most common presenting injury was laceration (87.2%), preceded by abrasion (59.6%), then contusion (51.1%), fracture (23.4%), and hematoma (2.1%).  The most common region involved in RTA was head & neck with 86.17%. Maximal deaths occurred within 3-6 hours following an RTA. The most common cause of death was an injury to the brain and its associated vessels. There is no significant correlation noted between the patterns of injury and the cause of death of subjects (p<0.05). Conclusion Our study shows the pattern of injuries and causes of death via RTA, as there is no study conducted in this region. It will be useful to Law Enforcement agencies in implementing rules and regulations in preventing RTA and public awareness. Keywords: Road Traffic accidents, Autopsy findings