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Background: While there have been clinical studies to prove the efficacy of testosterone in increasing the stretched penile size in cases of micropenis, giving various results, attempts to summarize them have been scant. Objectives: This systematic review summarizes the efficacy of testosterone in the treatment of micropenis. Materials and methods: This systematic review sought original English research articles in which patients with isolated micropenis were administered testosterone to increase their stretched penile length in PubMed, Scopus, and ProQuest. Search keywords were “micropenis” and “hormone”. We then assessed the selected articles using the Joanna Briggs Institute (JBI) Checklist for Case Series. Results: Of the 1,181 articles, 8 articles (n = 171) met the inclusion criteria for this systematic review. Assessment of the articles showed that various hormones are used in the treatment of micropenis. Discussion: Various hormones, mainly testosterone, are effective in treating micropenis. It is found that testosterone, especially topical testosterone, can increase stretched penile length 2 until 3 times the pre-treatment length in 3 months of treatment. However, other hormone treatments can also increase stretched penile length, but its effect is not as significant as testosterone. Dual hormone therapy is also used for micropenis and other hormone deficiencies to increase the efficacy of the results. Conclusions: Hormone therapy is effective in increasing the stretched penile size in cases of micropenis. The use of hormones needs to be tailored to each patient to ensure optimal result.