The main idea in this research used quercetin (QT) as a stabilizing agent to prepare CuO nanoparticle (NPs). QT is a pigment which exists from plants, fruits, and in some medicines. It contains numerous hydroxyl groups, works as a complexing agent and a self-assembly agent. The prepared CuO-NPs were characterized by Fourier transformed infrared (FT-IR), X-ray diffraction (XRD), scanning and transmission electron microscopy (SEM and TEM), and energy-dispersive X-ray analysis (EDX). The structure investigation confirm that the CuO-NPs were polycrystalline nature having a monoclinic crystalline form and showed (111̅ ) and (111) preferential orientations. The estimated particle sizes by XRD, TEM, and SEM ranged from 12.03 to 15.3 nm. Surface analysis displayed that homogeneously distributed CuO-NPs with a spherical shape. On the other hand, synthesized CuO-NPs were tested for anticancer activity on the human breast. The infected cell (MCF-7) uses MTT (3-(4,5-dimethyl-2-triazolyl)-2,5-diphenyl-2tetrazolium bromide) test. The inferred CuO-NPs clarify high anticancer cytotoxicity of the (MCF-7) with an IC50 μM value of 57.6 and 42.8 µg/mL for 24 and 72 h respectively.

, (CHT) was been prepared from the reaction of pyridine-2,6-dicarboxylic acid with semicarbazide using microwave irradiation in solid state. The ligand is reacted with some transition metal(II) ions to form complexes of the type [Co(CHT)]Cl 2 , [Fe(CHT) Cl]Cl and [M(CHT)Cl 2 ] where (M=Mn(II), Ni(II), Cu(II) and Zn(II)). Complexes of the type [Ni(CHT)(PPh 3)]Cl 2 and [M(CHT)(PPh 3)Cl]Cl where (M=Mn(II), Fe(II), Co(II), Cu(II) and Zn(II)), were prepared by the reaction of the above complexes with triphenylphosphine(PPh 3) in a 1:1 molar ratio. All the complexes were characterized by (C,H,N) analysis, metal content analysis, molar conductance, magnetic moment measurements, electronic and IR spectroscopy, as well as the ligand was characterized by 1 H , 13 C-NMR. The electronic spectra and magnetic measurements indicate that the complexes have octahedral environment around the metal ions, except cobalt complex have square planer geometry.

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In this research, a new ligand 3,4,6,13,14,16-hexaazatricyclo [16,2,2,28,11] tetracosane-2,5,7,12,15,17-hexaone), (DHC) was prepared from the reaction of cyclohexane-1,4-dicarboxylic acid with semicarbazide using microwave irradiation in solid state. Then, it was reacted with some transition metal(II) ions to form complexes of the type [M(DHC)Cl 2 ], [M(DHC)]Cl 2 , where M = Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and Zn(II). Adducts of the type [M(DHC)(PPh 3)Cl]Cl and [M(DHC)(PPh 3)]Cl 2 , were prepared by the reaction of the above complexes with triphenylphosphine in a 1:1 molar ratio. The prepared complexes and adducts were characterized by (C,H,N) analysis, metal content analysis, molar conductance, magnetic moment measurements, electronic and IR spectroscopy, as well as the ligand was characterized by 1 H, 13 C-NMR spectroscopy. The electronic spectra and magnetic measurements indicate that the complexes have octahedral environment around the metal ions.

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