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To monitor the temperature distribution of a cell and its changes under varied conditions is currently a technical challenge. A variety of non-contact methods used for measuring cellular temperature have been developed, where changes of local temperature at cell-level and sub-cell-level are indirectly calculated through the changes in intensity, band-shape, bandwidth, lifetime or polarization anisotropy of the fluorescence spectra recorded from the nano-sized fluorescent materials pre-injected into the target cell. Unfortunately, the optical properties of the fluorescent nano-materials may be affected by complicated intracellular environment, leading to unexpected measurement errors and controversial arguments. Here, we attempted to offer an alternative approach for measuring the absolute increments of local temperature in micro-Testing Zones induced by live cells. In this method, built-in high-performance micro-thermocouple arrays and double-stabilized system with a stability of 10 mK were applied. Increments of local temperature close to adherent human hepatoblastoma (HepG2) cells were continuously recorded for days without stimulus, showing frequent fluctuations within 60 mK and a maximum increment by 285 mK. This method may open a door for real-time recording of the absolute local temperature increments of individual cells, therefore offering valuable information for cell biology and clinical therapy in the field of cancer research.

We study the bit-error rate performance of different subcarrier phase-shift keying systems with carrier phase errors (CPE) in lognormal turbulence channels where the CPE is modeled as a Tikhonov random variable. The CPE induced asymptotic noise reference losses for the studied systems are quantified analytically by introducing the lognormal-Nakagami fading as an auxiliary channel model. The auxiliary channel method used in this study can be potentially applied to other performance analysis problems involving the lognormal channels.

No abstract

High-performance thin film lithium niobate (LN) electro-optic modulators with low cost are in demand. Based on photolithography and wet etching, we experimentally demonstrate a thin film LN Mach-Zehnder modulator with a 3 dB bandwidth exceeding 110 GHz, which shows the potential of boosting the throughput and reducing cost. The fabricated modulator also exhibits a comparable low half-wave voltage-length product of ∼2.37 V • cm, a high extinction ratio of >23 dB, and the propagation loss of optical waveguides of ∼0.2 dB=cm. Besides, six-level pulse amplitude modulation up to 250 Gb=s is successfully achieved.