Globally, stroke is a primary reason for death and lasting disability (Benjamin et al., 2019). Inflammation is critical in the course of a stroke and is closely linked to prognosis (Anrather & Iadecola, 2016).The inflammatory response following stroke involves immune cell infiltration, glial cell activation, and the emission of diverse neurotoxic molecules, such as pro-inflammatory cytokines, matrix metalloproteinases, and nitric oxide synthase, which further exacerbates neurological damage by causing endothelial cell damage, bloodbrain barrier (BBB) disruption, and neuronal apoptosis (Jayaraj et al., 2019). Therefore, immunotherapy targeting the post-stroke