The potential pharmaceutical application of nanoparticles has led to the toxicity within the male reproductive system. In the present study, the effects of silver nanoparticles (Ag-NPs) on hematological parameters, free radical generation, antioxidant system, sperm parameters, and organ histo-morphometry in male rats were investigated. Ag-NPs were produced by the reduction of silver ions, while the formation of which was monitored by UV–visible spectrophotometry. Zeta potential, transmission, and scanning electron microscopies were applied for the characterization of AgNPs. A total of 30 rats were divided into 6 groups and were sub-dermally exposed to Ag-NPs at the dosage of 0 (control), 10, and 50 mg/kg bodyweight (bw) doses for either 7 or 28 days. Ag-NP administration altered hematological indices and caused dose-dependent decreases in sperm motility, velocity, kinematic parameters, concentrations of luteinizing hormone, follicle-stimulating hormone, and testosterone. In the epididymis and testis, the concentrations of malondialdehyde and peroxide increases while superoxide dismutase, catalase, reduced glutathione, and total thiol group decreases. These findings suggest that Ag-NP triggered hormonal imbalance and induce oxidative stress in testis and epididymis; which negatively affect sperm parameters of male rats.

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Polyamidoamine functionalized graphene oxide−SBA-15 mesoporous composite (PGOSBA) was synthesized, characterized, and examined for aqueous adsorption of metals (As(III) and Cd(II)) and emerging pollutants (ciprofloxacin, ivermectin, and tetracycline). The adsorption data were explained with kinetics and adsorption isotherm models. PGOSBA is mesoporous, but has lower Brunauer−Emmett−Teller (BET) surface area and pore dimensions in comparison to the aminefunctionalized SBA-15 (SBA-15-NH 2 ). Infrared spectra peaks peculiar to the individual constituents were observed in the PGOSBA, which exhibited thermal stability in-between those of its SBA-15-NH 2 and graphene oxide (GO) constituents. The basic structural lattices of individual constituents were unaffected in the PGOSBA morphology, which was covered by GO sheet-like structures. The adsorption of Cd(II), As(III), ciprofloxacin, and ivermectin attained equilibrium at 240, 20, 180, and 720 min, respectively. The adsorption rate data for Cd(II) fitted the pseudosecond-order kinetics model, while As(III), ciprofloxacin, and ivermectin adsorption fitted the fractal pseudo-second-order kinetics model better. PGOSBA exhibited one optimum adsorption pH for Cd(II) (pH 5), while two pH points were recorded for ivermectin (a lower peak at pH 3 and a higher one at pH 9). The Cd(II) and ivermectin adsorption processes were spontaneous and endothermic; an increase in temperature up to ≈30 °C slightly enhanced Cd(II) adsorption (≤5%), as well as ivermectin (≥15%), but to an extent; a higher temperature increase (≈40 °C) may result in lower adsorption (≤2%) than at ≈30 °C. Multiple sorption phenomena including electrostatic interactions, multilayer adsorption due to π−π interactions, as well as pore filling were involved in the pollutants removal processes. The PGOSBA adsorption capacities for Cd(II), As(III), tetracycline, and ciprofloxacin are 92.4, 22.3, 29.2, and 24.6 mg/g, respectively, while it is 291.8 μg/g for ivermectin. The adsorbent could lower ivermectin in lowconcentration ivermectin solutions (<80 μg/L) to less than 8.5 μg/L. The PGOSBA reusability for ivermectin adsorption over three consecutive cycles of adsorption, desorption, and reuse was ≥95%. These results imply that the PGOSBA adsorbent would be economically viable for potential use in water treatment processes.

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