The development of e-LKPD assisted by flips PDF professional is used to develop students' HOTS in science lessons. The purpose of this research is to develop an e-LKPD assisted by a flip PDF professional that is valid, practical, and effective. The research method used is development research using the ADDIE development model. Based on the results of data analysis obtained from several validators, it shows that the developed e-LKPD obtained an average percentage score of 93% with a very valid and good category to use. The results of practicality in the use of e-LKPD when learning obtained a percentage of 88.7% with a good category. In knowing the increase in students' HOTS, the N-Gain test was carried out and obtained a value of 0.65 with moderate criteria, which means that the e-LKPD assisted by flip PDF professionals is quite effective in increasing students' HOTS. The results of student responses to the use of the developed e-LKPD showed an average percentage score of 58.94%. Based on the analysis results obtained, the e-LKPD assisted by flip PDF professionals in science lessons to improve students' Higher Order Thinking Skills is feasible to use.