Background: The optimal allocation of limited donated hearts to patients on the waiting list is one of the top priorities in heart transplantation management. We developed a simulation model of the US waiting list for heart transplantation to investigate the potential impacts of allocation policies on several outcomes such as pre- and posttransplant mortality. Methods: We used data from the United Network for Organ Sharing (UNOS) and the Scientific Registry of Transplant Recipient (SRTR) to simulate the heart allocation system. The model is validated by comparing the outcomes of the simulation with historical data. We also adapted fairness schemes studied in welfare economics to provide a framework to assess the fairness of allocation policies for transplantation. We considered three allocation policies, each a modification to the current UNOS allocation policy, and analyzed their performance via simulation. The first policy broadens the geographical allocation zones, the second modifies the health status order for receiving hearts, and the third prioritizes patients according to their waiting time. Results: Our results showed that the allocation policy similar to the current UNOS practice except that it aggregates the three immediate geographical allocation zones, improves the health outcomes, and is “closer” to an optimal fair policy compared to all other policies considered in this study. Specifically, this policy could have saved 319 total deaths (out of 3738 deaths) during the 2006 to 2014 time horizon, in average. This policy slightly differs from the current UNOS allocation policy and allows for easy implementation. Conclusion: We developed a model to compare the outcomes of heart allocation policies. Combining the three immediate geographical zones in the current allocation algorithm could potentially reduce mortality rate and is closer to an optimal fair policy.
Identifying an efficient and fair allocation of limited donated hearts to patients on the waiting list is one of the top priorities in heart transplantation management. The recent heart allocation rule by the United Network for Organ Sharing (UNOS) has emphasized medical urgency to address the heart transplant crisis by further dividing the previous sickest patient group into three subgroups. However, there is a significant debate on optimality and fairness of this policy because although it can help reduce pre‐transplant mortality, it may reduce post‐transplant survival. We undertake a rigorous study to address this debate by measuring the impacts of a variety of perspectives on the waiting list and patients. We show that the optimal policy of our proposed fluid model is a dynamic priority rule, and provide insight on the impact of fairness constraints on such priorities. We quantify the price that the society pays for following a medical urgency approach, which favors the sickest patients, compared to a utilitarian approach, which seeks to maximize total quality‐adjusted life years (QALYs). Our results, produced by a validated simulation model, reveal that the said price is 7.7% of total QALYs and increases to 11% by considering a broader regional sharing aligned with four‐hour heart cold ischemic time. We study other relevant objectives/measures in transplantation and our results show that the utilitarian policy outperforms the medical urgency policy in other measures as well. Our analysis provides novel insights on optimal patient allocation and sheds light on the debate around this challenging problem.
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