In order to compare the clinical eff ect of platelet rich plasma-therapy and local negative pressure-therapy on the background of pharmacotherapy with Icariin and combined platelet rich plasma-therapy in combination with shock-wave therapy and vacuum device therapy on the background of pharmacotherapy with Icariin in the treatment of erectile dysfunction of arterial and arterial-venous origin, 50 patients of the «Men’s Health» Clinic (Kiev) were examined with using clinical, laboratory and sonographic methods. Based on the results of the study, the high eff ectiveness of platelet rich plasma-therapy, shock-wave therapy and vacuum device -therapy and Icariin combinationsuse in the arterial and arterial-venous erectile dysfunction therapy in comparison with platelet rich plasma-therapy and vacuum device therapy and Icariin. According to our data intracavernosus activation of plate-cells was conducted by shock-wave method in a first time ever.