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Purpose of the study: comparative assessment of hematological and autoimmune status of patients with Graves’ disease (GD). Materials and methods. 43 GD patients aged between 19 and 64 years, 26 of which were women and 17 were men, have been examined. Assessment of hemograms of examined patients helped to reveal anemia in 28(65.1%) examined patients (group I). In 15 (34.9%) patients (group II) anemia was not detected. Mild anemia was diagnosed in 25 (89.3%), moderate anemia – in 3 (10.7%) patients. Hemoglobin, hematocrit, erythrocyte count and erythrocyte indices MCV, MCH, MCHC, serum Fe and ferritin status was chaecked in clinical analysis. The immune status was assessed by the level of CD3+, CD4+, CD8+, CD19+, CD4+/CD8+, CEC, Ef, TSHRAb and hormonal status by the level of TSH, T4 free. Results. Microcytic anemia was determined in 15 (53.6%) patients, normocytic - in 12 (42.8%), macrocytic - in 1 (3.5%) patient due to volume of erythrocytes’ MCV. According to morphological criteria of МСН (mean content of hemoglobin in erythrocyte) anemia hypochromic type of anemia was noted in 15 (53.6%) patients, normochromic - in 12 (42.8%), hyperchromic - in 1 (3.5%) patient. In 15 (53.6%%) patients in the group I microcytic - hypochromic anemia was diagnosed, which is characteristic for iron-deficient anemia; in 12 (42.8%) patients was verified normocyticnormochromic anemia, which has morphological parameters of anemia of chronic diseases and in 1 (3.5%) patient macrocytic-hyperchromic anemia. Comparative assessment of HGB level and indicators of iron metabolism in GD patients with anemia detected decreasing of HGB by 20%, serum Fe by 20%, ferritin by 29% compared to the corresponding control values. More pronounced depletion of the iron depot (ferritin) due to the fact that the development of anemia is preceded by a “latent iron deficiency”, an indicator of which is ferritin. Conclusions. GD is characterized by high frequency of anemia (65.1%), mostly mild form (89.3%), microcytichypochromic (53.6%), characteristic of iron deficiency anemia. The severe hematological disorders, detected among GD patients with anemia are accompanied by deep autoimmune changes and hyperfunction of the thyroid gland.

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Objective. Identify the frequency of occurrence of various morphological types and different degrees of severity of anemia in patients with autoimmune thyroiditis. Material and methods.Were analyzed97 case histories of patients operated for autoimmune thyroiditis (AIT)in 2012. When assessing hematological parameters, two groups were identified: group 1 – patients with AIT with mild anemia (n = 72), age 45.7 ± 1.6, men - 5 (6.9%), women - 67 (93, 1%); group 2 - patients with AIT with moderate anemia (n = 25), age 40.0 ± 2.3, men - 1 (4%), women - 24 (96%). In the clinical analysis of blood, hemoglobin, hematocrit, the number of erythrocytes and erythrocyte indexes of MCV, MCH, MCHC were determined. Results. By morphological type in patients with AIT with mild anemia, the hypochromic type was observed in 56 (77.8%) patients, normochromic - in 16 (22.2%) patients. In moderate anemia, this tendency was more pronouned: hypochromic type of anemia was detected in 23 (92%) patients, normochromic type - in 1(4%) and hyperchromic in 1(4%). Thus, in patients with AIT, mild anemia was more often determined (in 72.4%), then moderate anemia (in 25.7%). With moderate severity of anemia, microcytic (84%) and hypochromic (92%) types of anemia were more often observed. With mild anemia, the same types of anemias were observed, but with a lower frequency (76.4% and 77.8%, respectively). Conclusion. The hemogram in patients with AIT was characterized by a more frequent development of mild anemia (72.4%). With mild anemia, hematological disorders were characterized by microcytic (76.4%) and hypochromic (77.8%) types of anemia. Similar, but more pronounced disorders were observed in moderate anemia: microcytic 84% and hypochromic 92%, which is characteristic for iron deficiency anemia

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