This review article aims to investigate the genotypic profiles of Plasmodium falciparum and Plasmodium vivax isolates collected across a wide geographic region and their association with resistance to anti-malarial drugs used in Indonesia. A systematic review was conducted between 1991 and date. Search engines, such as PubMed, Science Direct, and Google Scholar, were used for articles published in English and Indonesian to search the literature. Of the 471 initially identified studies, 61 were selected for 4316 P. falciparum and 1950 P. vivax individual infections. The studies included 23 molecular studies and 38 therapeutic efficacy studies. K76T was the most common pfcrt mutation. K76N (2.1%) was associated with the haplotype CVMNN. By following dihydroartemisinin–piperaquine (DHA–PPQ) therapy, the mutant pfmdr1 alleles 86Y and 1034C were selected. Low prevalence of haplotype N86Y/Y184/D1246Ypfmdr1 reduces susceptibility to AS–AQ. SNP mutation pvmdr1 Y976F reached 96.1% in Papua and East Nusa Tenggara. Polymorphism analysis in the pfdhfr gene revealed 94/111 (84.7%) double mutants S108N/C59R or S108T/A16V in Central Java. The predominant pfdhfr haplotypes (based on alleles 16, 51, 59,108, 164) found in Indonesia were ANCNI, ANCSI, ANRNI, and ANRNL. Some isolates carried A437G (35.3%) or A437G/K540E SNPs (26.5%) in pfdhps. Two novel pfdhps mutant alleles, I588F/G and K540T, were associated with six pfdhps haplotypes. The highest prevalence of pvdhfr quadruple mutation (F57L/S58R/T61M/S117T) (61.8%) was detected in Papua. In pvdhps, the only polymorphism before and after 2008 was 383G mutation with 19% prevalence. There were no mutations in the pfk13 gene reported with validated and candidate or associated k13 mutation. An increased copy number of pfpm2, associated with piperaquine resistance, was found only in cases of reinfection. Meanwhile, mutation of pvk12 and pvpm4 I165V is unlikely associated with ART and PPQ drug resistance. DHA–PPQ is still effective in treating uncomplicated falciparum and vivax malaria. Serious consideration should be given to interrupt local malaria transmission and dynamic patterns of resistance to anti-malarial drugs to modify chemotherapeutic policy treatment strategies. The presence of several changes in pfk13 in the parasite population is of concern and highlights the importance of further evaluation of parasitic ART susceptibility in Indonesia. Graphical Abstract

The paper shows that air quality aspects rise from forest fires in Indonesia and they have associations with a wide range of adverse health outcomes, including respiratory health problems. Due to the unpredictable nature of forest fires, it is challenging for public health authorities to evaluate the potential exposures before they occur reliably. Using GIS software, zoning was made om Riau Province, Indonesia. The data shows that the highest fire hotspot was in 2015 by 12,854 and the lowest was 527 in 2017 as well as the lowest Respiratory Disorder Cases in 2017 was 371,044. The Finding proves that smoke has a significant negative effect on increasing respiratory problems Therefore, it also indicates that smoke and haze forecastings are effective tools and challenging to be developed that can be used as public health predictions and establish a suitable policy on forest fires. However, their inherent uncertainties limit their widespread adoption. Observed measurements from air quality monitoring networks and remote sensing platforms are more reliable, but they are inherently retrospective.

Malaria is one of the global health problems that is faced by many countries, including Indonesia. This study aimed to examine the association between demographic and attitude factors with malaria prevention in the rural areas of Purworejo District, Indonesia. A community survey was conducted in Purworejo District that involved 147 respondents by using simple random sampling to select the respondents. A questionnaire interview was used to collect data about demographic factors, attitudes, and malaria prevention practices. A Chi-square test was performed to examine the association between demographic and attitude factors with the practice of malaria prevention in the community. Among 147 respondents, 80 (54.4%) respondents conducted malaria prevention practice using bed mosquito net in their own houses. Demographic factors such as education level (p<0.001), occupation (p=0.016), and attitude factor (p=0.006) were significantly associated with the use of bed mosquito net for malaria prevention practice. Meanwhile, 63 (42.9%) respondents used ventilation mosquito net for malaria prevention practice. Demographic factors such as education level (p<0.001), age groups (p=0.005), occupation (p=0.002), and attitude factor (p=0.001) were associated significantly with the use of ventilation mosquito net for malaria prevention practice. Overall, malaria prevention by using both bed and ventilation mosquito nets were very low percentages. Keywords             : Malaria, prevention practice, mosquito net, IndonesiaCorrespondence   : farindira.vesti@gmail.com