We have investigated a microwave–assisted synthesis of 4(3H)–quinazolinones by condensation of anthranilic acid, orthoesters (or formic acid) and substituted anilines, using Keggin-type heteropolyacids (H3PW12O40∙13H2O, H4SiW12O40∙13H2O, H4SiMo12O40∙13H2O or H3PMo12O40∙13H2O) as catalysts. We found that the the use of H3PW12O40∙13H2O acid coupled to microwave irradiation allows a solvent-free, rapid (~13 min) and high-yielding reaction.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.