Background: Burning Mouth Syndrome (BMS) is a common condition that affects menopausal women and patients experience a severe burning sensation in their mouth. So far there have been no definitive treatment for this disease. Objectives: The present study was undertaken to evaluate the efficacy of zinc supplement in improving the symptoms of burning mouth syndrome. Patients and Methods: Sixty patients were enrolled in this study; they were randomly divided to two groups. Patients in the intervention group received replacement therapy twice daily, which continued for three months. In the control group, placebo capsules, which were completely similar to zinc sulfate capsules, were administered two times daily. Results: Burning sensation severity in the two groups after the intervention was significantly different (P = 0.001). Conclusions: It can be concluded that zinc supplement might decrease the intensity of burning mouth syndrome in patients with zinc deficiency.

Background: Osteoporosis is one of the chronic diseases of the skeletal system characterized by low bone mineral density. Mouth saliva is made up of complex proteins and ions including calcium, potassium, and sodium. Since calcium is an important component of the skeletal system and exists also in saliva, in this study we examined the relationship between salivary calcium and osteoporosis. Methods: In this analytical cross-sectional study, unstimulated saliva samples were collected from 60 patients with rheumatoid arthritis who had history of steroid use. They were divided into equal groups of osteoporosis, osteopenia, and control. All data were analyzed using ANOVA statistical test in SPSS (v.18). Results: The average calcium concentration in groups of osteoporosis and osteopenia was 1.7 ± 0.70 and 1.7 ± 0.76, respectively. Also, the average frequency of dry mouth in osteoporosis and osteopenia groups was 5 and 6, respectively. The observed differences were not statistically significant between the groups (P = 0.4). Conclusions: According to the present study, there is no significant relationship between salivary and serum calcium and osteoporosis caused by treatment with glucocorticoid.