Background Stroke is the second leading cause of death worldwide. The role of zinc as a new predictor of stroke was considered. Methods This prospective study was conducted in Ayatollah Rouhani Hospital within a year on 100 stroke and 100 control patients. Findings The difference in zinc serum level in two groups was significant (deficiency: 3 (3%) in patients versus 20 (20%) in control group, normal: 25 (25%) versus 54 (54%), and increased level: 72 (72%) versus 26 (26%); p < 0.001). Difference in zinc serum levels was statistically significant with ischemic heart disease (deficiency: 0 cases (0%), normal: 8 cases (24%), increased level: 24 cases (75%), p = 0.003). Increases in zinc serum level were significantly correlated with the frequency of hemorrhagic and ischemic patients (deficiency: 3 (3.3%) hemorrhagic versus 0 (0%) ischemic; normal: 19 (21%) versus 6 (60%), increased level: 68 (75.6%) versus 4 (40%); p = 0.025). Regression logistics showed that ischemic heart disease (p < 0.001; OR = 28.29, %95 CI: 5.53; 144.87), hyperlipidemia (p < 0.001; OR = 0.26, %95 CI: 0.12; 0.56), and zinc serum level (p < 0.001, OR = 15.53, %95 CI: 4.03; 59.83) each had a significant role. Conclusions Babol stroke patients are prone to increased zinc serum level as a new parameter. Ischemic heart disease, increased levels of zinc, and hyperlipidemia were found to be probable predictor factors for stroke in Babol.

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Background and Purpose: Stroke is the second leading cause of death worldwide. The role of zinc as a contributing factor in the pathogenesis of stroke was considered.Results: This cross-sectional study on 100 stroke patients in Ayatollah Rouhani Hospital and 100 control group from cohort master plan "Ageing and health projects Amirkola was conducted. Zinc levels Serum simultaneously with other blood tests in the early hours of hospitalization. Zinc serum level was defined 70 to 120 micrograms per deciliter.Findings: The difference in mean of zinc level in patients and control group was not significant (102.6±47.7 in control group vs 100.9±35.8 in patient, p=0.7). Difference in zinc Serum level had statically significant with IHD (under70 0 cases (0), 70 to120 8 cases (24), 120 and upper24 cases (75), p=0.003) and with type of stroke (under70 (3(3.3) hemorrhagic vs 0(0) ischemic), 70 to 120(19(21) vs6 (60)), 120 and upper68 (75.6) vs4 (40), p=0.025) and also with patient and control group (under70 (3(3) in patient's vs 20(20) control group), 70 to 120(25(25) vs54 (54)), 120 and upper72 (72) vs26 (26), p<0001). In patients group 72(73.5) of cases had zinc serum level above 120. HLP difference was significant in patient and control group (50(50) in control group vs 35(35) in patients, p=0.04). Regression logistic show that IHD (p<0001, OR=30, CI=6-152), HLP (p<0001, OR=4, CI=9.09-1.85), zinc serum level (p<0001, OR=15.5, CI=4-59.8) had significant role.Conclusions: Zinc serum levels, Ischemic Heart Disease, Hyperlipidemia were most risk factor that play role in Babol stroke patients.