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A one-pot and pseudo four-component synthesis of spiro[diindeno[1,2-b:2 0 ,1 0 -e]pyridine-11,3 0 -indoline]-trione derivatives by cyclo-condensation reaction of isatins, 1,3-indandione, and ammonium acetate in refluxing acetic acid is reported.

A simple and efficient procedure for the synthesis of 2,2'-(2-oxoindoline-3,3-diyl)bis(1H-indene-1,3(2H)-dione) derivatives, 2,2'-(2-oxo-1,2-dihydroacenaphthylene-1,1-diyl)bis(1H-indene-1,3(2H)-dione) and 2,2'-(1,3-dioxo-2,3-dihydro-1H-indene-2,2-diyl)bis(1H-indene-1,3(2H)-dione) by the reaction of 1,3-indandione and isatins or acenaphthylene-1,2-dione or ninhydrine in ethanol under ultrasonic irradiation in the presence of p-TSA is reported. The advantages of this method are the use of an inexpensive and readily available catalyst, easy work-up, good yields, and the use of ethanol as a solvent that is considered to be relatively environmentally benign.

A novel, clean, one-pot and three-component synthesis of new spiro[chromeno[2,3-d]pyrimidine-5,3 0indoline]-2 0 ,6(7H)-diones and spiro[chromeno[2,3-c]pyrazole-4,3 0 -indoline]-2 0 ,5(6H)-diones via cyclocondensation reaction of isatins, 1,3-cyclohexadiones, and 2-methylpyrimidine-4,6-diol or 3-methyl-1phenyl-1H-pyrazol-5-ol, in aqueous media is reported.

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