Keywords: Click chemistry / Green chemistry / Water / Micelles / Surfactants / Mannich bases / β-Amino ketones A micellar solution of anionic, cationic or neutral surfactants can be used as an excellent medium for three-component Mannich reactions of aldehydes, amines, and ketones at room temperature. Sodium dodecylsulfate turned out to efficiently catalyze the reaction in neutral pure water (pH ≈ 7), and the corresponding desired β-amino ketones precipitate while the reactions proceedes. This method provides a novel and improved modification of the three-component Mannich

The Michael addition of indoles to Į,ȕ-unsaturated electron deficient compounds was catalyzed efficiently at room temperature in acidic micellar solution of sodium dodecyl sulfate (SDS). The substitution on the indole nucleus occurred exclusively at the 3-position in good to excellent yields, and no N-alkylation products were observed.

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The aim of the research described was to study Rb 2 HPW 12 O 40 as a green and heterogeneous catalyst for the Mannich reaction. One-pot multi-component condensation of an aldehyde, an amine and a ketone at ambient temperature affords the corresponding β-amino ketones using novel nano-sized Rb 2 HPW 12 O 40 . Simple purification, short reaction time and high yield are some of the advantages of this reaction. Also, the catalyst can be readily isolated. The nano catalyst Rb 2 HPW 12 O 40 has been characterized by Fourier transform infrared spectroscopy, X-ray powder diffraction and scanning electron microscopy.

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